1kw4: Difference between revisions

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[[Image:1kw4.jpg|left|200px]]<br /><applet load="1kw4" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1kw4.jpg|left|200px]]<br /><applet load="1kw4" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1kw4, resolution 1.75Å" />

'''Polyhomeotic SAM domain structure'''<br />

==Overview==

The polycomb group (PcG) proteins are important in the maintenance of, stable repression patterns during development. Several PcG members contain, a protein protein interaction module called a SAM domain (also known as, SPM, PNT and HLH). Here we report the high-resolution structure of the SAM, domain of polyhomeotic (Ph). Ph-SAM forms a helical polymer structure, providing a likely mechanism for the extension of PcG complexes. The, structure of the polymer resembles that formed by the SAM domain of, another transcriptional repressor, TEL. The formation of these polymer, structures by SAM domains in two divergent repressors suggests a conserved, mode of repression involving a higher order chromatin structure.

The polycomb group (PcG) proteins are important in the maintenance of stable repression patterns during development. Several PcG members contain a protein protein interaction module called a SAM domain (also known as SPM, PNT and HLH). Here we report the high-resolution structure of the SAM domain of polyhomeotic (Ph). Ph-SAM forms a helical polymer structure, providing a likely mechanism for the extension of PcG complexes. The structure of the polymer resembles that formed by the SAM domain of another transcriptional repressor, TEL. The formation of these polymer structures by SAM domains in two divergent repressors suggests a conserved mode of repression involving a higher order chromatin structure.

==About this Structure==

1KW4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1KW4 OCA].

1KW4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW4 OCA].

==Reference==

Line 13:

[[Category: Drosophila melanogaster]]

[[Category: Single protein]]

[[Category: Bowie, J.U.]]

[[Category: Bowie, J U.]]

[[Category: Gingery, M.]]

[[Category: Kim, C.A.]]

[[Category: Kim, C A.]]

[[Category: Pilpa, R.M.]]

[[Category: Pilpa, R M.]]

[[Category: polycomb group]]

[[Category: polymer]]

[[Category: sam domain]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20 19~~:57:~~17 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:38:35 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1kw4.jpg|left|200px]]<br /><applet load="1kw4" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1kw4.jpg|left|200px]]<br /><applet load="1kw4" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1kw4, resolution 1.75&Aring;" />
 '''Polyhomeotic SAM domain structure'''<br />
 ==Overview==
-The polycomb group (PcG) proteins are important in the maintenance of, stable repression patterns during development. Several PcG members contain, a protein protein interaction module called a SAM domain (also known as, SPM, PNT and HLH). Here we report the high-resolution structure of the SAM, domain of polyhomeotic (Ph). Ph-SAM forms a helical polymer structure, providing a likely mechanism for the extension of PcG complexes. The, structure of the polymer resembles that formed by the SAM domain of, another transcriptional repressor, TEL. The formation of these polymer, structures by SAM domains in two divergent repressors suggests a conserved, mode of repression involving a higher order chromatin structure.
+The polycomb group (PcG) proteins are important in the maintenance of stable repression patterns during development. Several PcG members contain a protein protein interaction module called a SAM domain (also known as SPM, PNT and HLH). Here we report the high-resolution structure of the SAM domain of polyhomeotic (Ph). Ph-SAM forms a helical polymer structure, providing a likely mechanism for the extension of PcG complexes. The structure of the polymer resembles that formed by the SAM domain of another transcriptional repressor, TEL. The formation of these polymer structures by SAM domains in two divergent repressors suggests a conserved mode of repression involving a higher order chromatin structure.
 ==About this Structure==
-KW4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1KW4 OCA].
+KW4 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KW4 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Drosophila melanogaster]]
 [[Category: Single protein]]
-[[Category: Bowie, J.U.]]
+[[Category: Bowie, J U.]]
 [[Category: Gingery, M.]]
-[[Category: Kim, C.A.]]
+[[Category: Kim, C A.]]
-[[Category: Pilpa, R.M.]]
+[[Category: Pilpa, R M.]]
 [[Category: polycomb group]]
 [[Category: polymer]]
 [[Category: sam domain]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 19:57:17 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:38:35 2008''