Corticosteroid-binding globulin: Difference between revisions
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Corticosteroid-binding globulin is a very important blood protein that functions not merely as a passive carrier of cortisol, but also as a ready reservoir of the hormone for release at sites of inflammation. It also acts as a buffer to keep the level of blood cortisol constant and thus, maintains homeostasis. Work is still being done, not just in fully elucidating the molecular mechanism of its function, but also in its interaction with various tissues in the body, and this can have great implications on our understanding of metabolic diseases, as well as infection and immunity. | Corticosteroid-binding globulin is a very important blood protein that functions not merely as a passive carrier of cortisol, but also as a ready reservoir of the hormone for release at sites of inflammation. It also acts as a buffer to keep the level of blood cortisol constant and thus, maintains homeostasis. Work is still being done, not just in fully elucidating the molecular mechanism of its function, but also in its interaction with various tissues in the body, and this can have great implications on our understanding of metabolic diseases, as well as infection and immunity. | ||
==3D structures of corticosteroid-binding protein== | |||
[[2v95]] – rSer-A6 – rat<br /> | |||
[[2vdx]] – hSer-A6 (mutant) - human<br /> | |||
[[2vdx]] – hSer-A6 (mutant) + cortisol | |||
==Resources== | ==Resources== | ||
