1lbd: Difference between revisions

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[[Image:1lbd.gif|left|200px]]<br />

[[Image:1lbd.gif|left|200px]]<br /><applet load="1lbd" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1lbd" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1lbd, resolution 2.7Å" />

'''LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA'''<br />

==Overview==

The crystal structure of the human retinoid-X receptor RXR-alpha, ligand-binding domain reveals a previously undiscovered fold of an, antiparallel alpha-helical sandwich, packed as dimeric units. Two helices, and one loop form the homodimerization surface, and hydrophobic heptad, repeats participate in stabilizing the fold. The existence of a, ligand-binding pocket is proposed that would allow 9-cis retinoic acid to, interact with different functional modules, including the AF-2 activating, domain. Several lines of evidence indicate that the overall structure is a, prototype fold of ligand-binding domains of nuclear receptors.

The crystal structure of the human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed as dimeric units. Two helices and one loop form the homodimerization surface, and hydrophobic heptad repeats participate in stabilizing the fold. The existence of a ligand-binding pocket is proposed that would allow 9-cis retinoic acid to interact with different functional modules, including the AF-2 activating domain. Several lines of evidence indicate that the overall structure is a prototype fold of ligand-binding domains of nuclear receptors.

==About this Structure==

1LBD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1LBD OCA].

1LBD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBD OCA].

==Reference==

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[[Category: Bourguet, W.]]

[[Category: Moras, D.]]

[[Category: SPINE, Structural.Proteomics.in.Europe.]]

[[Category: SPINE, Structural Proteomics in Europe.]]

[[Category: nuclear receptor]]

[[Category: spine]]

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[[Category: transcription factor]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 17~~:58:~~28 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:43:25 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1lbd.gif|left|200px]]<br />
+[[Image:1lbd.gif|left|200px]]<br /><applet load="1lbd" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1lbd" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1lbd, resolution 2.7&Aring;" />
 '''LIGAND-BINDING DOMAIN OF THE HUMAN NUCLEAR RECEPTOR RXR-ALPHA'''<br />
 ==Overview==
-The crystal structure of the human retinoid-X receptor RXR-alpha, ligand-binding domain reveals a previously undiscovered fold of an, antiparallel alpha-helical sandwich, packed as dimeric units. Two helices, and one loop form the homodimerization surface, and hydrophobic heptad, repeats participate in stabilizing the fold. The existence of a, ligand-binding pocket is proposed that would allow 9-cis retinoic acid to, interact with different functional modules, including the AF-2 activating, domain. Several lines of evidence indicate that the overall structure is a, prototype fold of ligand-binding domains of nuclear receptors.
+The crystal structure of the human retinoid-X receptor RXR-alpha ligand-binding domain reveals a previously undiscovered fold of an antiparallel alpha-helical sandwich, packed as dimeric units. Two helices and one loop form the homodimerization surface, and hydrophobic heptad repeats participate in stabilizing the fold. The existence of a ligand-binding pocket is proposed that would allow 9-cis retinoic acid to interact with different functional modules, including the AF-2 activating domain. Several lines of evidence indicate that the overall structure is a prototype fold of ligand-binding domains of nuclear receptors.
 ==About this Structure==
-LBD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LBD OCA].
+LBD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LBD OCA].
 ==Reference==
@@ Line 16: / Line 15: @@
 [[Category: Bourguet, W.]]
 [[Category: Moras, D.]]
-[[Category: SPINE, Structural.Proteomics.in.Europe.]]
+[[Category: SPINE, Structural Proteomics in Europe.]]
 [[Category: nuclear receptor]]
 [[Category: spine]]
@@ Line 23: / Line 22: @@
 [[Category: transcription factor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:58:28 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:43:25 2008''