1lxa: Difference between revisions
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New page: left|200px<br /><applet load="1lxa" size="450" color="white" frame="true" align="right" spinBox="true" caption="1lxa, resolution 2.6Å" /> '''UDP N-ACETYLGLUCOSAMI... |
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[[Image:1lxa.jpg|left|200px]]<br /><applet load="1lxa" size=" | [[Image:1lxa.jpg|left|200px]]<br /><applet load="1lxa" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1lxa, resolution 2.6Å" /> | caption="1lxa, resolution 2.6Å" /> | ||
'''UDP N-ACETYLGLUCOSAMINE ACYLTRANSFERASE'''<br /> | '''UDP N-ACETYLGLUCOSAMINE ACYLTRANSFERASE'''<br /> | ||
==Overview== | ==Overview== | ||
UDP-N-acetylglucosamine 3-O-acyltransferase (LpxA) catalyzes the transfer | UDP-N-acetylglucosamine 3-O-acyltransferase (LpxA) catalyzes the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-N-acetylglucosamine. LpxA is the first enzyme in the lipid A biosynthetic pathway and is a target for the design of antibiotics. The x-ray crystal structure of LpxA has been determined to 2.6 angstrom resolution and reveals a domain motif composed of parallel beta strands, termed a left-handed parallel beta helix (L beta H). This unusual fold displays repeated violations of the protein folding constraint requiring right-handed crossover connections between strands of parallel beta sheets and may be present in other enzymes that share amino acid sequence homology to the repeated hexapeptide motif of LpxA. | ||
==About this Structure== | ==About this Structure== | ||
1LXA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine_O-acyltransferase Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.129 2.3.1.129] Full crystallographic information is available from [http:// | 1LXA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Active as [http://en.wikipedia.org/wiki/Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine_O-acyltransferase Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.129 2.3.1.129] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LXA OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Escherichia coli]] | [[Category: Escherichia coli]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Roderick, S | [[Category: Roderick, S L.]] | ||
[[Category: acyltransferase]] | [[Category: acyltransferase]] | ||
[[Category: lipid a biosynthesis]] | [[Category: lipid a biosynthesis]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:49:21 2008'' | ||
