1m4r: Difference between revisions

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==Overview==

Interleukin-22 (IL-10-related T cell-derived inducible, factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family., Recombinant human IL-22 (hIL-22) was found to activate the signal, transducers and activators of transcription factors 1 and 3 as well as, acute phase reactants in several hepatoma cell lines, suggesting its, involvement in the inflammatory response. The crystallographic structure, of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS, method. Contrary to IL-10, the hIL-22 dimer does not present an, interpenetration of the secondary-structure elements belonging to the two, distinct polypeptide chains but results from interface interactions, between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a, homodimer of IL-10 is required for signaling, hIL-22 most probably, interacts with its receptor as a monomer.

Interleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant human IL-22 (hIL-22) was found to activate the signal transducers and activators of transcription factors 1 and 3 as well as acute phase reactants in several hepatoma cell lines, suggesting its involvement in the inflammatory response. The crystallographic structure of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS method. Contrary to IL-10, the hIL-22 dimer does not present an interpenetration of the secondary-structure elements belonging to the two distinct polypeptide chains but results from interface interactions between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a homodimer of IL-10 is required for signaling, hIL-22 most probably interacts with its receptor as a monomer.

==About this Structure==

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[[Category: Colau, D.]]

[[Category: Dumoutier, L.]]

[[Category: Nagem, R.A.P.]]

[[Category: Nagem, R A.P.]]

[[Category: Ogata, C.]]

[[Category: Polikarpov, I.]]

[[Category: Renauld, J.C.]]

[[Category: Renauld, J C.]]

[[Category: crystal structure]]

[[Category: cytokines]]

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[[Category: interleukin-22 (il-22)]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:51:30 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Interleukin-22 (IL-10-related T cell-derived inducible, factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family., Recombinant human IL-22 (hIL-22) was found to activate the signal, transducers and activators of transcription factors 1 and 3 as well as, acute phase reactants in several hepatoma cell lines, suggesting its, involvement in the inflammatory response. The crystallographic structure, of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS, method. Contrary to IL-10, the hIL-22 dimer does not present an, interpenetration of the secondary-structure elements belonging to the two, distinct polypeptide chains but results from interface interactions, between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a, homodimer of IL-10 is required for signaling, hIL-22 most probably, interacts with its receptor as a monomer.
+Interleukin-22 (IL-10-related T cell-derived inducible factor/IL-TIF/IL-22) is a novel cytokine belonging to the IL-10 family. Recombinant human IL-22 (hIL-22) was found to activate the signal transducers and activators of transcription factors 1 and 3 as well as acute phase reactants in several hepatoma cell lines, suggesting its involvement in the inflammatory response. The crystallographic structure of recombinant hIL-22 has been solved at 2.0 A resolution using the SIRAS method. Contrary to IL-10, the hIL-22 dimer does not present an interpenetration of the secondary-structure elements belonging to the two distinct polypeptide chains but results from interface interactions between monomers. Structural differences between these two cytokines, revealed by the crystallographic studies, clearly indicate that, while a homodimer of IL-10 is required for signaling, hIL-22 most probably interacts with its receptor as a monomer.
 ==About this Structure==
@@ Line 15: / Line 15: @@
 [[Category: Colau, D.]]
 [[Category: Dumoutier, L.]]
-[[Category: Nagem, R.A.P.]]
+[[Category: Nagem, R A.P.]]
 [[Category: Ogata, C.]]
 [[Category: Polikarpov, I.]]
-[[Category: Renauld, J.C.]]
+[[Category: Renauld, J C.]]
 [[Category: crystal structure]]
 [[Category: cytokines]]
@@ Line 25: / Line 25: @@
 [[Category: interleukin-22 (il-22)]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:22:03 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:51:30 2008''