3cde: Difference between revisions
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==About this Structure== | ==About this Structure== | ||
[[3cde]] is a 2 chain structure | [[3cde]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3CDE OCA]. | ||
==See Also== | ==See Also== | ||
Revision as of 11:46, 20 October 2012
Crystal structure of HCV NS5B polymerase with a novel Pyridazinone inhibitor
Template:ABSTRACT PUBMED 18457949
About this Structure
3cde is a 2 chain structure with sequence from Hepatitis c virus. Full crystallographic information is available from OCA.
See Also
Reference
- Li LS, Zhou Y, Murphy DE, Stankovic N, Zhao J, Dragovich PS, Bertolini T, Sun Z, Ayida B, Tran CV, Ruebsam F, Webber SE, Shah AM, Tsan M, Showalter RE, Patel R, Lebrun LA, Bartkowski DM, Nolan TG, Norris DA, Kamran R, Brooks J, Sergeeva MV, Kirkovsky L, Zhao Q, Kissinger CR. Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)- 5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments. Bioorg Med Chem Lett. 2008 Jun 1;18(11):3446-55. Epub 2008 Mar 5. PMID:18457949 doi:10.1016/j.bmcl.2008.02.072
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Categories:
- Pages with broken file links
- Hepatitis c virus
- RNA-directed RNA polymerase
- Han, Q.
- Kissinger, C R.
- Showalter, R E.
- Zhao, Q.
- Atp-binding
- Host-virus interaction
- Hydrolase
- Metal-binding
- Nucleotide-binding
- Nucleotidyltransferase
- Protein-ligand complex
- Ribonucleoprotein
- Rna replication
- Rna-binding
- Rna-directed rna polymerase
- Transcription
- Transcription regulation
- Transferase
- Viral nucleoprotein
- Virion
