1me3: Difference between revisions
New page: left|200px<br /><applet load="1me3" size="450" color="white" frame="true" align="right" spinBox="true" caption="1me3, resolution 1.2Å" /> '''High Resolution Cryst... |
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[[Image:1me3.jpg|left|200px]]<br /><applet load="1me3" size=" | [[Image:1me3.jpg|left|200px]]<br /><applet load="1me3" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1me3, resolution 1.2Å" /> | caption="1me3, resolution 1.2Å" /> | ||
'''High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)'''<br /> | '''High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)'''<br /> | ||
==Overview== | ==Overview== | ||
The crystal structures of two hydroxymethyl ketone inhibitors complexed to | The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions. | ||
==About this Structure== | ==About this Structure== | ||
1ME3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi] with P10 as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | 1ME3 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Trypanosoma_cruzi Trypanosoma cruzi] with <scene name='pdbligand=P10:'>P10</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ME3 OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Trypanosoma cruzi]] | [[Category: Trypanosoma cruzi]] | ||
[[Category: Brinen, L | [[Category: Brinen, L S.]] | ||
[[Category: Ellman, J | [[Category: Ellman, J A.]] | ||
[[Category: Huang, L.]] | [[Category: Huang, L.]] | ||
[[Category: P10]] | [[Category: P10]] | ||
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[[Category: non-covalent inhibitor]] | [[Category: non-covalent inhibitor]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:54:19 2008'' | ||
Revision as of 11:54, 21 February 2008
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High Resolution Crystal Structure Analysis Of Cruzain non-covalently Bound To A Hydroxymethyl Ketone Inhibitor (II)
Overview
The crystal structures of two hydroxymethyl ketone inhibitors complexed to the cysteine protease cruzain have been determined at 1.1 and 1.2 A resolution, respectively. These high resolution crystal structures provide the first structures of non-covalent inhibitors bound to cruzain. A series of compounds were prepared and tested based upon the structures providing further insight into the key binding interactions.
About this Structure
1ME3 is a Single protein structure of sequence from Trypanosoma cruzi with P10 as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structures of reversible ketone-Based inhibitors of the cysteine protease cruzain., Huang L, Brinen LS, Ellman JA, Bioorg Med Chem. 2003 Jan 2;11(1):21-9. PMID:12467703
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