1mmj: Difference between revisions

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[[Image:1mmj.gif|left|200px]]<br /><applet load="1mmj" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1mmj.gif|left|200px]]<br /><applet load="1mmj" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1mmj, resolution 2.2Å" />

'''Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706'''<br />

==Overview==

The crystal structure of porcine pancreatic elastase (PPE) complexed with, a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution., FR136706 fits snugly into the extended active site pocket. The benzene, moiety of FR136706 induced dramatic movement of the side chain moiety of, Arg217 and both moieties formed a pi-pi interaction, which has never been, found previously in structures of PPE complexed with inhibitors. This, novel interaction mode may lead to design of new types of inhibitors.

The crystal structure of porcine pancreatic elastase (PPE) complexed with a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution. FR136706 fits snugly into the extended active site pocket. The benzene moiety of FR136706 induced dramatic movement of the side chain moiety of Arg217 and both moieties formed a pi-pi interaction, which has never been found previously in structures of PPE complexed with inhibitors. This novel interaction mode may lead to design of new types of inhibitors.

==About this Structure==

1MMJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with SO4, CA and FR1 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1MMJ OCA].

1MMJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=FR1:'>FR1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MMJ OCA].

==Reference==

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[[Category: chymotrypsin family]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Tue Nov 20~~ 21:31:~~54 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:56:41 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1mmj.gif|left|200px]]<br /><applet load="1mmj" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1mmj.gif|left|200px]]<br /><applet load="1mmj" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1mmj, resolution 2.2&Aring;" />
 '''Porcine pancreatic elastase complexed with a potent peptidyl inhibitor, FR136706'''<br />
 ==Overview==
-The crystal structure of porcine pancreatic elastase (PPE) complexed with, a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution., FR136706 fits snugly into the extended active site pocket. The benzene, moiety of FR136706 induced dramatic movement of the side chain moiety of, Arg217 and both moieties formed a pi-pi interaction, which has never been, found previously in structures of PPE complexed with inhibitors. This, novel interaction mode may lead to design of new types of inhibitors.
+The crystal structure of porcine pancreatic elastase (PPE) complexed with a potent peptidyl inhibitor, FR136706, was solved at 2.2A resolution. FR136706 fits snugly into the extended active site pocket. The benzene moiety of FR136706 induced dramatic movement of the side chain moiety of Arg217 and both moieties formed a pi-pi interaction, which has never been found previously in structures of PPE complexed with inhibitors. This novel interaction mode may lead to design of new types of inhibitors.
 ==About this Structure==
-MMJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with SO4, CA and FR1 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1MMJ OCA].
+MMJ is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa] with <scene name='pdbligand=SO4:'>SO4</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=FR1:'>FR1</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Pancreatic_elastase Pancreatic elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.36 3.4.21.36] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1MMJ OCA].
 ==Reference==
@@ Line 20: / Line 20: @@
 [[Category: chymotrypsin family]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Nov 20 21:31:54 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:56:41 2008''