1mp8: Difference between revisions

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==Overview==

Protein kinases are important drug targets in human cancers, inflammation, and metabolic diseases. This report presents the structures of kinase, domains for three cancer-associated protein kinases: ephrin receptor A2, (EphA2), focal adhesion kinase (FAK), and Aurora-A. The expression, profiles of EphA2, FAK, and Aurora-A in carcinomas suggest that inhibitors, of these kinases may have inherent potential as therapeutic agents. The, structures were determined from crystals grown in nanovolume droplets, which produced high-resolution diffraction data at 1.7, 1.9, and 2.3 A for, FAK, Aurora-A, and EphA2, respectively. The FAK and Aurora-A structures, are the first determined within two unique subfamilies of human kinases, and all three structures provide new insights into kinase regulation and, the design of selective inhibitors.

Protein kinases are important drug targets in human cancers, inflammation, and metabolic diseases. This report presents the structures of kinase domains for three cancer-associated protein kinases: ephrin receptor A2 (EphA2), focal adhesion kinase (FAK), and Aurora-A. The expression profiles of EphA2, FAK, and Aurora-A in carcinomas suggest that inhibitors of these kinases may have inherent potential as therapeutic agents. The structures were determined from crystals grown in nanovolume droplets, which produced high-resolution diffraction data at 1.7, 1.9, and 2.3 A for FAK, Aurora-A, and EphA2, respectively. The FAK and Aurora-A structures are the first determined within two unique subfamilies of human kinases, and all three structures provide new insights into kinase regulation and the design of selective inhibitors.

==About this Structure==

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[[Category: Single protein]]

[[Category: Transferase]]

[[Category: Cronin, C.N.]]

[[Category: Cronin, C N.]]

[[Category: Knuth, M.W.]]

[[Category: Knuth, M W.]]

[[Category: McRee, D.E.]]

[[Category: McRee, D E.]]

[[Category: Nelson, C.G.]]

[[Category: Nelson, C G.]]

[[Category: Nowakowski, J.]]

[[Category: Pavletich, N.P.]]

[[Category: Pavletich, N P.]]

[[Category: Rodgers, J.]]

[[Category: Sang, B.C.]]

[[Category: Sang, B C.]]

[[Category: Scheibe, D.N.]]

[[Category: Scheibe, D N.]]

[[Category: Swanson, R.V.]]

[[Category: Swanson, R V.]]

[[Category: Thompson, D.A.]]

[[Category: Thompson, D A.]]

[[Category: ADP]]

[[Category: tyrosine protein kinase]]

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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:37 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-Protein kinases are important drug targets in human cancers, inflammation, and metabolic diseases. This report presents the structures of kinase, domains for three cancer-associated protein kinases: ephrin receptor A2, (EphA2), focal adhesion kinase (FAK), and Aurora-A. The expression, profiles of EphA2, FAK, and Aurora-A in carcinomas suggest that inhibitors, of these kinases may have inherent potential as therapeutic agents. The, structures were determined from crystals grown in nanovolume droplets, which produced high-resolution diffraction data at 1.7, 1.9, and 2.3 A for, FAK, Aurora-A, and EphA2, respectively. The FAK and Aurora-A structures, are the first determined within two unique subfamilies of human kinases, and all three structures provide new insights into kinase regulation and, the design of selective inhibitors.
+Protein kinases are important drug targets in human cancers, inflammation, and metabolic diseases. This report presents the structures of kinase domains for three cancer-associated protein kinases: ephrin receptor A2 (EphA2), focal adhesion kinase (FAK), and Aurora-A. The expression profiles of EphA2, FAK, and Aurora-A in carcinomas suggest that inhibitors of these kinases may have inherent potential as therapeutic agents. The structures were determined from crystals grown in nanovolume droplets, which produced high-resolution diffraction data at 1.7, 1.9, and 2.3 A for FAK, Aurora-A, and EphA2, respectively. The FAK and Aurora-A structures are the first determined within two unique subfamilies of human kinases, and all three structures provide new insights into kinase regulation and the design of selective inhibitors.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Single protein]]
 [[Category: Transferase]]
-[[Category: Cronin, C.N.]]
+[[Category: Cronin, C N.]]
-[[Category: Knuth, M.W.]]
+[[Category: Knuth, M W.]]
-[[Category: McRee, D.E.]]
+[[Category: McRee, D E.]]
-[[Category: Nelson, C.G.]]
+[[Category: Nelson, C G.]]
 [[Category: Nowakowski, J.]]
-[[Category: Pavletich, N.P.]]
+[[Category: Pavletich, N P.]]
 [[Category: Rodgers, J.]]
-[[Category: Sang, B.C.]]
+[[Category: Sang, B C.]]
-[[Category: Scheibe, D.N.]]
+[[Category: Scheibe, D N.]]
-[[Category: Swanson, R.V.]]
+[[Category: Swanson, R V.]]
-[[Category: Thompson, D.A.]]
+[[Category: Thompson, D A.]]
 [[Category: ADP]]
 [[Category: tyrosine protein kinase]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:25:04 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:57:37 2008''