1mt6: Difference between revisions

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==Overview==

The SET domain contains the catalytic center of lysine methyltransferases, that target the N-terminal tails of histones and regulate chromatin, function. Here we report the structure of the SET7/9 protein in the, absence and presence of its cofactor product, S-adenosyl-L-homocysteine, (AdoHcy). A knot within the SET domain helps form the methyltransferase, active site, where AdoHcy binds and lysine methylation is likely to occur., A structure-guided comparison of sequences within the SET protein family, suggests that the knot substructure and active site environment are, conserved features of the SET domain.

The SET domain contains the catalytic center of lysine methyltransferases that target the N-terminal tails of histones and regulate chromatin function. Here we report the structure of the SET7/9 protein in the absence and presence of its cofactor product, S-adenosyl-L-homocysteine (AdoHcy). A knot within the SET domain helps form the methyltransferase active site, where AdoHcy binds and lysine methylation is likely to occur. A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain.

==About this Structure==

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[[Category: Single protein]]

[[Category: Devarakonda, S.]]

[[Category: Harp, J.M.]]

[[Category: Harp, J M.]]

[[Category: Jacobs, S.A.]]

[[Category: Jacobs, S A.]]

[[Category: Khorasanizadeh, S.]]

[[Category: Kim, Y.]]

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[[Category: set domain]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Feb ~~15 16~~:25:34 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:58:46 2008''

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@@ Line 4: / Line 4: @@
 ==Overview==
-The SET domain contains the catalytic center of lysine methyltransferases, that target the N-terminal tails of histones and regulate chromatin, function. Here we report the structure of the SET7/9 protein in the, absence and presence of its cofactor product, S-adenosyl-L-homocysteine, (AdoHcy). A knot within the SET domain helps form the methyltransferase, active site, where AdoHcy binds and lysine methylation is likely to occur., A structure-guided comparison of sequences within the SET protein family, suggests that the knot substructure and active site environment are, conserved features of the SET domain.
+The SET domain contains the catalytic center of lysine methyltransferases that target the N-terminal tails of histones and regulate chromatin function. Here we report the structure of the SET7/9 protein in the absence and presence of its cofactor product, S-adenosyl-L-homocysteine (AdoHcy). A knot within the SET domain helps form the methyltransferase active site, where AdoHcy binds and lysine methylation is likely to occur. A structure-guided comparison of sequences within the SET protein family suggests that the knot substructure and active site environment are conserved features of the SET domain.
 ==About this Structure==
@@ Line 15: / Line 15: @@
 [[Category: Single protein]]
 [[Category: Devarakonda, S.]]
-[[Category: Harp, J.M.]]
+[[Category: Harp, J M.]]
-[[Category: Jacobs, S.A.]]
+[[Category: Jacobs, S A.]]
 [[Category: Khorasanizadeh, S.]]
 [[Category: Kim, Y.]]
@@ Line 26: / Line 26: @@
 [[Category: set domain]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:25:34 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 13:58:46 2008''