1ncv: Difference between revisions

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[[Image:1ncv.gif|left|200px]]<br />

[[Image:1ncv.gif|left|200px]]<br /><applet load="1ncv" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1ncv" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1ncv" />

'''DETERMINATION CC-CHEMOKINE MCP-3, NMR, 7 STRUCTURES'''<br />

==Overview==

MCP-3 is a beta chemokine consisting of 76 amino acid residues. It has, been described to be involved in the activation of all leukocytic cells, activation mediated by the presence of multiple binding sites on the, target cells. Its three-dimensional structure has been studied by making, use of two-dimensional 1H NMR spectroscopy. MCP-3 exhibits the same, monomeric structure as the other chemokines, i.e., a three-stranded, antiparallel beta sheet covered on one face by an alpha helix. Although it, belongs to the same subfamily as RANTES (Chung et al., 1995; Faitbrother, et al., 1994) and hMIP-1beta (Lodi et al., 1994), the MCP-3 dimer is, folded like IL-8 with the so-called alphabeta sandwich structural motif., Structural and sequence analysis gives clear indications suggesting that, the other MCP chemokines may have the same quaternary structure, contrary, to the other beta chemokines.

MCP-3 is a beta chemokine consisting of 76 amino acid residues. It has been described to be involved in the activation of all leukocytic cells, activation mediated by the presence of multiple binding sites on the target cells. Its three-dimensional structure has been studied by making use of two-dimensional 1H NMR spectroscopy. MCP-3 exhibits the same monomeric structure as the other chemokines, i.e., a three-stranded antiparallel beta sheet covered on one face by an alpha helix. Although it belongs to the same subfamily as RANTES (Chung et al., 1995; Faitbrother et al., 1994) and hMIP-1beta (Lodi et al., 1994), the MCP-3 dimer is folded like IL-8 with the so-called alphabeta sandwich structural motif. Structural and sequence analysis gives clear indications suggesting that the other MCP chemokines may have the same quaternary structure, contrary to the other beta chemokines.

==About this Structure==

1NCV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1NCV OCA].

1NCV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCV OCA].

==Reference==

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[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Bernassau, J.M.]]

[[Category: Bernassau, J M.]]

[[Category: Darbon, H.]]

[[Category: Ferrara, P.]]

[[Category: Guillemot, J.C.]]

[[Category: Guillemot, J C.]]

[[Category: Meunier, S.]]

[[Category: beta-chemokine]]

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[[Category: structure]]

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@@ Line 1: / Line 1: @@
-[[Image:1ncv.gif|left|200px]]<br />
+[[Image:1ncv.gif|left|200px]]<br /><applet load="1ncv" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1ncv" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1ncv" />
 '''DETERMINATION CC-CHEMOKINE MCP-3, NMR, 7 STRUCTURES'''<br />
 ==Overview==
-MCP-3 is a beta chemokine consisting of 76 amino acid residues. It has, been described to be involved in the activation of all leukocytic cells, activation mediated by the presence of multiple binding sites on the, target cells. Its three-dimensional structure has been studied by making, use of two-dimensional 1H NMR spectroscopy. MCP-3 exhibits the same, monomeric structure as the other chemokines, i.e., a three-stranded, antiparallel beta sheet covered on one face by an alpha helix. Although it, belongs to the same subfamily as RANTES (Chung et al., 1995; Faitbrother, et al., 1994) and hMIP-1beta (Lodi et al., 1994), the MCP-3 dimer is, folded like IL-8 with the so-called alphabeta sandwich structural motif., Structural and sequence analysis gives clear indications suggesting that, the other MCP chemokines may have the same quaternary structure, contrary, to the other beta chemokines.
+MCP-3 is a beta chemokine consisting of 76 amino acid residues. It has been described to be involved in the activation of all leukocytic cells, activation mediated by the presence of multiple binding sites on the target cells. Its three-dimensional structure has been studied by making use of two-dimensional 1H NMR spectroscopy. MCP-3 exhibits the same monomeric structure as the other chemokines, i.e., a three-stranded antiparallel beta sheet covered on one face by an alpha helix. Although it belongs to the same subfamily as RANTES (Chung et al., 1995; Faitbrother et al., 1994) and hMIP-1beta (Lodi et al., 1994), the MCP-3 dimer is folded like IL-8 with the so-called alphabeta sandwich structural motif. Structural and sequence analysis gives clear indications suggesting that the other MCP chemokines may have the same quaternary structure, contrary to the other beta chemokines.
 ==About this Structure==
-NCV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1NCV OCA].
+NCV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NCV OCA].
 ==Reference==
@@ Line 14: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Bernassau, J.M.]]
+[[Category: Bernassau, J M.]]
 [[Category: Darbon, H.]]
 [[Category: Ferrara, P.]]
-[[Category: Guillemot, J.C.]]
+[[Category: Guillemot, J C.]]
 [[Category: Meunier, S.]]
 [[Category: beta-chemokine]]
@@ Line 28: / Line 27: @@
 [[Category: structure]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:20:28 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:04:45 2008''