1oko: Difference between revisions

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==Overview==

The structure of the tetrameric Pseudomonas aeruginosa lectin I (PA-IL) in, complex with galactose and calcium was determined at 1.6 A resolution, and, the native protein was solved at 2.4 A resolution. Each monomer adopts a, beta-sandwich fold with ligand binding site at the apex. All galactose, hydroxyl groups, except O1, are involved in a hydrogen bond network with, the protein and O3 and O4 also participate in the co-ordination of the, calcium ion. The stereochemistry of calcium galactose binding is, reminiscent of that observed in some animal C-type lectins. The structure, of the complex provides a framework for future design of anti-bacterial, compounds.

The structure of the tetrameric Pseudomonas aeruginosa lectin I (PA-IL) in complex with galactose and calcium was determined at 1.6 A resolution, and the native protein was solved at 2.4 A resolution. Each monomer adopts a beta-sandwich fold with ligand binding site at the apex. All galactose hydroxyl groups, except O1, are involved in a hydrogen bond network with the protein and O3 and O4 also participate in the co-ordination of the calcium ion. The stereochemistry of calcium galactose binding is reminiscent of that observed in some animal C-type lectins. The structure of the complex provides a framework for future design of anti-bacterial compounds.

==About this Structure==

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[[Category: lectin]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-The structure of the tetrameric Pseudomonas aeruginosa lectin I (PA-IL) in, complex with galactose and calcium was determined at 1.6 A resolution, and, the native protein was solved at 2.4 A resolution. Each monomer adopts a, beta-sandwich fold with ligand binding site at the apex. All galactose, hydroxyl groups, except O1, are involved in a hydrogen bond network with, the protein and O3 and O4 also participate in the co-ordination of the, calcium ion. The stereochemistry of calcium galactose binding is, reminiscent of that observed in some animal C-type lectins. The structure, of the complex provides a framework for future design of anti-bacterial, compounds.
+The structure of the tetrameric Pseudomonas aeruginosa lectin I (PA-IL) in complex with galactose and calcium was determined at 1.6 A resolution, and the native protein was solved at 2.4 A resolution. Each monomer adopts a beta-sandwich fold with ligand binding site at the apex. All galactose hydroxyl groups, except O1, are involved in a hydrogen bond network with the protein and O3 and O4 also participate in the co-ordination of the calcium ion. The stereochemistry of calcium galactose binding is reminiscent of that observed in some animal C-type lectins. The structure of the complex provides a framework for future design of anti-bacterial compounds.
 ==About this Structure==
@@ Line 27: / Line 27: @@
 [[Category: lectin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 09:59:18 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:18:51 2008''