1opg: Difference between revisions

Line 1:

[[Image:1opg.gif|left|200px]]<br />

[[Image:1opg.gif|left|200px]]<br /><applet load="1opg" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1opg" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1opg, resolution 2.Å" />

'''OPG2 FAB FRAGMENT'''<br />

==Overview==

Cell surface receptors called integrins mediate diverse cell adhesion, phenomena through recognition of the sequence arginine-glycine-aspartic, acid (RGD) present in proteins such as fibronectin and fibrinogen., Platelet aggregation in hemostasis is mediated by the binding of, fibrinogen to the gpIIb/IIIa integrin. The OPG2 antibody binds the, gpIIb/IIIa receptor and acts as a ligand mimic due to the presence of an, arginine-tyrosine-aspartic acid (RYD) sequence in the CDR3 loop of the, heavy chain. The RYD loop and side chains are ordered in the 2.0-A, resolution crystal structure of the Fab fragment from this antireceptor, antibody. Moreover, the RYD loop assumes two clearly defined conformations, that may correspond to the orientations of the loop in the free state or, bound to integrin. This molecule will serve as a tool for understanding, protein-integrin recognition in platelet aggregation and other, RGD-mediated cell adhesion interactions.

Cell surface receptors called integrins mediate diverse cell adhesion phenomena through recognition of the sequence arginine-glycine-aspartic acid (RGD) present in proteins such as fibronectin and fibrinogen. Platelet aggregation in hemostasis is mediated by the binding of fibrinogen to the gpIIb/IIIa integrin. The OPG2 antibody binds the gpIIb/IIIa receptor and acts as a ligand mimic due to the presence of an arginine-tyrosine-aspartic acid (RYD) sequence in the CDR3 loop of the heavy chain. The RYD loop and side chains are ordered in the 2.0-A resolution crystal structure of the Fab fragment from this antireceptor antibody. Moreover, the RYD loop assumes two clearly defined conformations that may correspond to the orientations of the loop in the free state or bound to integrin. This molecule will serve as a tool for understanding protein-integrin recognition in platelet aggregation and other RGD-mediated cell adhesion interactions.

==About this Structure==

1OPG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].

1OPG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].

==Reference==

Line 14:

Line 13:

[[Category: Homo sapiens]]

[[Category: Single protein]]

[[Category: Ely, K.R.]]

[[Category: Ely, K R.]]

[[Category: Kodandapani, R.]]

[[Category: Veerapandian, B.]]

[[Category: cell adhesion molecule]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Sun Nov 18 09~~:39:~~22 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:20:12 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1opg.gif|left|200px]]<br />
+[[Image:1opg.gif|left|200px]]<br /><applet load="1opg" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1opg" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1opg, resolution 2.&Aring;" />
 '''OPG2 FAB FRAGMENT'''<br />
 ==Overview==
-Cell surface receptors called integrins mediate diverse cell adhesion, phenomena through recognition of the sequence arginine-glycine-aspartic, acid (RGD) present in proteins such as fibronectin and fibrinogen., Platelet aggregation in hemostasis is mediated by the binding of, fibrinogen to the gpIIb/IIIa integrin. The OPG2 antibody binds the, gpIIb/IIIa receptor and acts as a ligand mimic due to the presence of an, arginine-tyrosine-aspartic acid (RYD) sequence in the CDR3 loop of the, heavy chain. The RYD loop and side chains are ordered in the 2.0-A, resolution crystal structure of the Fab fragment from this antireceptor, antibody. Moreover, the RYD loop assumes two clearly defined conformations, that may correspond to the orientations of the loop in the free state or, bound to integrin. This molecule will serve as a tool for understanding, protein-integrin recognition in platelet aggregation and other, RGD-mediated cell adhesion interactions.
+Cell surface receptors called integrins mediate diverse cell adhesion phenomena through recognition of the sequence arginine-glycine-aspartic acid (RGD) present in proteins such as fibronectin and fibrinogen. Platelet aggregation in hemostasis is mediated by the binding of fibrinogen to the gpIIb/IIIa integrin. The OPG2 antibody binds the gpIIb/IIIa receptor and acts as a ligand mimic due to the presence of an arginine-tyrosine-aspartic acid (RYD) sequence in the CDR3 loop of the heavy chain. The RYD loop and side chains are ordered in the 2.0-A resolution crystal structure of the Fab fragment from this antireceptor antibody. Moreover, the RYD loop assumes two clearly defined conformations that may correspond to the orientations of the loop in the free state or bound to integrin. This molecule will serve as a tool for understanding protein-integrin recognition in platelet aggregation and other RGD-mediated cell adhesion interactions.
 ==About this Structure==
-OPG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].
+OPG is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OPG OCA].
 ==Reference==
@@ Line 14: / Line 13: @@
 [[Category: Homo sapiens]]
 [[Category: Single protein]]
-[[Category: Ely, K.R.]]
+[[Category: Ely, K R.]]
 [[Category: Kodandapani, R.]]
 [[Category: Veerapandian, B.]]
 [[Category: cell adhesion molecule]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 18 09:39:22 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:20:12 2008''