1p7q: Difference between revisions

Line 4:

==Overview==

Leukocyte immunoglobulin-like receptor 1 (LIR-1), an inhibitory receptor, expressed on monocytes, dendritic cells and lymphocytes, regulates, cellular function by binding a broad range of classical and nonclassical, major histocompatibility complex (MHC) class I molecules, and the human, cytomegalovirus MHC class I homolog UL18. Here we describe the 3.4-A, crystal structure of a complex between the LIR-1 D1D2 domains and the MHC, class I molecule HLA-A2. LIR-1 contacts the mostly conserved, beta(2)-microglobulin and alpha3 domains of HLA-A2. The LIR-1 binding site, comprises residues at the interdomain hinge, and a patch at the D1 tip., The structure shows how LIR-1 recognizes UL18 and diverse MHC class I, molecules, and indicates that a similar mode of MHC class I recognition is, used by other LIR family members.

Leukocyte immunoglobulin-like receptor 1 (LIR-1), an inhibitory receptor expressed on monocytes, dendritic cells and lymphocytes, regulates cellular function by binding a broad range of classical and nonclassical major histocompatibility complex (MHC) class I molecules, and the human cytomegalovirus MHC class I homolog UL18. Here we describe the 3.4-A crystal structure of a complex between the LIR-1 D1D2 domains and the MHC class I molecule HLA-A2. LIR-1 contacts the mostly conserved beta(2)-microglobulin and alpha3 domains of HLA-A2. The LIR-1 binding site comprises residues at the interdomain hinge, and a patch at the D1 tip. The structure shows how LIR-1 recognizes UL18 and diverse MHC class I molecules, and indicates that a similar mode of MHC class I recognition is used by other LIR family members.

==Disease==

Line 16:

[[Category: Homo sapiens]]

[[Category: Protein complex]]

[[Category: Bjorkman, P.J.]]

[[Category: Bjorkman, P J.]]

[[Category: Thomas, L.M.]]

[[Category: Thomas, L M.]]

[[Category: Willcox, B.E.]]

[[Category: Willcox, B E.]]

[[Category: hla-a2/lir-1 complex]]

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on ~~Fri~~ Feb ~~15 16~~:39:10 2008''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:26:11 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 4: / Line 4: @@
 ==Overview==
-Leukocyte immunoglobulin-like receptor 1 (LIR-1), an inhibitory receptor, expressed on monocytes, dendritic cells and lymphocytes, regulates, cellular function by binding a broad range of classical and nonclassical, major histocompatibility complex (MHC) class I molecules, and the human, cytomegalovirus MHC class I homolog UL18. Here we describe the 3.4-A, crystal structure of a complex between the LIR-1 D1D2 domains and the MHC, class I molecule HLA-A2. LIR-1 contacts the mostly conserved, beta(2)-microglobulin and alpha3 domains of HLA-A2. The LIR-1 binding site, comprises residues at the interdomain hinge, and a patch at the D1 tip., The structure shows how LIR-1 recognizes UL18 and diverse MHC class I, molecules, and indicates that a similar mode of MHC class I recognition is, used by other LIR family members.
+Leukocyte immunoglobulin-like receptor 1 (LIR-1), an inhibitory receptor expressed on monocytes, dendritic cells and lymphocytes, regulates cellular function by binding a broad range of classical and nonclassical major histocompatibility complex (MHC) class I molecules, and the human cytomegalovirus MHC class I homolog UL18. Here we describe the 3.4-A crystal structure of a complex between the LIR-1 D1D2 domains and the MHC class I molecule HLA-A2. LIR-1 contacts the mostly conserved beta(2)-microglobulin and alpha3 domains of HLA-A2. The LIR-1 binding site comprises residues at the interdomain hinge, and a patch at the D1 tip. The structure shows how LIR-1 recognizes UL18 and diverse MHC class I molecules, and indicates that a similar mode of MHC class I recognition is used by other LIR family members.
 ==Disease==
@@ Line 16: / Line 16: @@
 [[Category: Homo sapiens]]
 [[Category: Protein complex]]
-[[Category: Bjorkman, P.J.]]
+[[Category: Bjorkman, P J.]]
-[[Category: Thomas, L.M.]]
+[[Category: Thomas, L M.]]
-[[Category: Willcox, B.E.]]
+[[Category: Willcox, B E.]]
 [[Category: hla-a2/lir-1 complex]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 16:39:10 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:26:11 2008''