1p9m: Difference between revisions
New page: left|200px<br /> <applet load="1p9m" size="450" color="white" frame="true" align="right" spinBox="true" caption="1p9m, resolution 3.65Å" /> '''Crystal structure o... |
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[[Image:1p9m.gif|left|200px]]<br /> | [[Image:1p9m.gif|left|200px]]<br /><applet load="1p9m" size="350" color="white" frame="true" align="right" spinBox="true" | ||
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caption="1p9m, resolution 3.65Å" /> | caption="1p9m, resolution 3.65Å" /> | ||
'''Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex'''<br /> | '''Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex'''<br /> | ||
==Overview== | ==Overview== | ||
Interleukin-6 (IL-6) is an immunoregulatory cytokine that activates a | Interleukin-6 (IL-6) is an immunoregulatory cytokine that activates a cell-surface signaling assembly composed of IL-6, the IL-6 alpha-receptor (IL-6Ralpha), and the shared signaling receptor gp130. The 3.65 angstrom-resolution structure of the extracellular signaling complex reveals a hexameric, interlocking assembly mediated by a total of 10 symmetry-related, thermodynamically coupled interfaces. Assembly of the hexameric complex occurs sequentially: IL-6 is first engaged by IL-6Ralpha and then presented to gp130in the proper geometry to facilitate a cooperative transition into the high-affinity, signaling-competent hexamer. The quaternary structures of other IL-6/IL-12 family signaling complexes are likely constructed by means of a similar topological blueprint. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1P9M is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | 1P9M is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1P9M OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Boulanger, M | [[Category: Boulanger, M J.]] | ||
[[Category: Brevnova, E | [[Category: Brevnova, E E.]] | ||
[[Category: Chow, D | [[Category: Chow, D C.]] | ||
[[Category: Garcia, K | [[Category: Garcia, K C.]] | ||
[[Category: cytokine]] | [[Category: cytokine]] | ||
[[Category: four helix bundle]] | [[Category: four helix bundle]] | ||
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[[Category: interleukin-6]] | [[Category: interleukin-6]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:26:36 2008'' | ||
Revision as of 12:26, 21 February 2008
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Crystal structure of the hexameric human IL-6/IL-6 alpha receptor/gp130 complex
Overview
Interleukin-6 (IL-6) is an immunoregulatory cytokine that activates a cell-surface signaling assembly composed of IL-6, the IL-6 alpha-receptor (IL-6Ralpha), and the shared signaling receptor gp130. The 3.65 angstrom-resolution structure of the extracellular signaling complex reveals a hexameric, interlocking assembly mediated by a total of 10 symmetry-related, thermodynamically coupled interfaces. Assembly of the hexameric complex occurs sequentially: IL-6 is first engaged by IL-6Ralpha and then presented to gp130in the proper geometry to facilitate a cooperative transition into the high-affinity, signaling-competent hexamer. The quaternary structures of other IL-6/IL-12 family signaling complexes are likely constructed by means of a similar topological blueprint.
Disease
Known diseases associated with this structure: Kaposi sarcoma, susceptibility to OMIM:[147620], Osteopenia/osteoporosis OMIM:[147620]
About this Structure
1P9M is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Hexameric structure and assembly of the interleukin-6/IL-6 alpha-receptor/gp130 complex., Boulanger MJ, Chow DC, Brevnova EE, Garcia KC, Science. 2003 Jun 27;300(5628):2101-4. PMID:12829785
Page seeded by OCA on Thu Feb 21 14:26:36 2008
