Tutorial:Basic Chemistry Topics: Difference between revisions

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==Possible Acetylation of  Mycobacterium Tuberculosis by Tobramycin CoA Complex==<StructureSection load='1m4d' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])' scene=''><div style='background-color:yellow;padding:10px;margin:10px;'>'''This tutorial is designed for high school (ages 14-19)'''.</div>
<StructureSection load='1m4d' size='500' side='right' caption='Structure of HMG-CoA reductase (PDB entry [[1dq8]])' scene=''><div style='background-color:yellow;padding:10px;margin:10px;'>'''This tutorial is designed for high school (ages 14-19)'''.</div>


==Possible Acetylation of Mycobacterium Tuberculosis by Tobramycin CoA Complex==
Throughout this tutorial we will be targeting basic chemistry topics. A scientific research article will be used to demonstrate key chemistry topics we will be discussing. These topics are vital to the understanding of more advanced chemistry. There are interactive molecules incorporated into the text to help your understanding.


Throughout this tutorial we will be targeting basic chemistry topics. The chemistry topics are based off a study conducted by a group of scientists. These topics are vital to the understanding of more advanced chemistry. There are interactive molecules incorporated into the text to help your understanding.
The summary of the research artical will be confusing, you are not expected to understand it completely to benefit from the tutorial. The reasearch artical is used as a refrence to demonstrate the chemistry topics we will be discussing.  


The study where this molecule was obtained is named "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin".  The study focused on AAC (2’)- Ic also known as aminoglycoside 2’- N- acetyltransferase. The scientist’s in the study determined the crystal structure of AAC (2’)-Ic from Mycobacterium tuberculosis. The specific fold of AAC (2’)-Ic places in the GNAT or GCN5-related N-acetyltransferase superfamily. Although the physiological function of AAC(2’)-Ic in not certain, the crystal structure they determined allowed them to hypothesize. Through the crystal structure they determined that this enzyme might acetylate mycothiol. Mycothiol is key biosynthetic intermediate and the major reducing agent in mycobacterium. This enzyme is capable of acetylating aminoglycosides bearing a 2’ amino group, when this occurs the aminoglycoside antibiotic becomes inactive.
==Summary: Scientific Research Artical==


I know the summary above is complex and confusing. I don't expect you to understand it completely. I am sharing this study with you because I am going to use it to explain basic chemistry concepts. We are going to dissect this scientific artical and pull the basic concepts from it and go into greater detail.  
 
The study where this molecule was obtained is named "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin". The study focused on AAC (2’)- Ic also known as aminoglycoside 2’- N- acetyltransferase. The scientist’s in the study determined the crystal structure of AAC (2’)-Ic from Mycobacterium tuberculosis. The specific fold of AAC (2’)-Ic places in the GNAT or GCN5-related N-acetyltransferase superfamily. Although the physiological function of AAC(2’)-Ic in not certain, the crystal structure they determined allowed them to hypothesize. Through the crystal structure they determined that this enzyme might acetylate mycothiol. Mycothiol is key biosynthetic intermediate and the major reducing agent in mycobacterium. This enzyme is capable of acetylating aminoglycosides bearing a 2’ amino group, when this occurs the aminoglycoside antibiotic becomes inactive.




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