Fibrin: Difference between revisions
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1n73b.png|left|250px|thumb|Crystal Structure of Fibrin from ''Petromyzon marinus'', [[1n73]]]] | [[Image:1n73b.png|left|250px|thumb|Crystal Structure of Fibrin from ''Petromyzon marinus'', [[1n73]]]] | ||
{{STRUCTURE_1n73| PDB=1n73 | SIZE= | {{STRUCTURE_1n73| PDB=1n73 | SIZE=400| SCENE=Fibrin/Cv/2 |right|CAPTION=Fibrin from ''Petromyzon marinus'', [[1n73]] }} | ||
[[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. [[Fibrinogen]] (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa). The images at the left and at the right correspond to one representative Fibrin, ''i.e.'' the crystal structure of Fibrin from ''Petromyzon marinus'' ([[1n73]]). | [[Fibrin]] (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. [[Fibrinogen]] (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa). The images at the left and at the right correspond to one representative Fibrin, ''i.e.'' the crystal structure of Fibrin from ''Petromyzon marinus'' ([[1n73]]). | ||
Revision as of 08:11, 31 October 2012
Fibrin (or Factor Ia, FIa) is a fibrous protein which when polymerized is involved in blood clotting. The polymerization epitopes of FIa are called A-knob and B-knob. Fibrinogen (Factor I, FI) is converted by thrombin to fibrin. Limited proteolysis of FI results in a fragment named D which when cross-linked by factor XIII is called double-D FIa (DDFIa). The images at the left and at the right correspond to one representative Fibrin, i.e. the crystal structure of Fibrin from Petromyzon marinus (1n73).
3D Structures of Fibrin
3h32 – hFIa peptide+ hFI α, β, γ chains – human
2q9i, 2z4e - hFIa B-knob+ hFI α, β, γ chains
2hlo, 1n86 - hFIa α, β, γ chains + peptide
1n8e - hFIa α, β, γ chains
1n73 - FIa α, β, γ chains + peptide – Sea lamprey
1fzc – hDDFIa+peptide
