1pdk: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /><applet load="1pdk" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pdk, resolution 2.4Å" /> '''PAPD-PAPK CHAPERONE-P... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1pdk.jpg|left|200px]]<br /><applet load="1pdk" size=" | [[Image:1pdk.jpg|left|200px]]<br /><applet load="1pdk" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1pdk, resolution 2.4Å" /> | caption="1pdk, resolution 2.4Å" /> | ||
'''PAPD-PAPK CHAPERONE-PILUS SUBUNIT COMPLEX FROM E.COLI P PILUS'''<br /> | '''PAPD-PAPK CHAPERONE-PILUS SUBUNIT COMPLEX FROM E.COLI P PILUS'''<br /> | ||
==Overview== | ==Overview== | ||
Many Gram-negative pathogens assemble architecturally and functionally | Many Gram-negative pathogens assemble architecturally and functionally diverse adhesive pili on their surfaces by the chaperone-usher pathway. Immunoglobulin-like periplasmic chaperones escort pilus subunits to the usher, a large protein complex that facilitates the translocation and assembly of subunits across the outer membrane. The crystal structure of the PapD-PapK chaperone-subunit complex, determined at 2.4 angstrom resolution, reveals that the chaperone functions by donating its G(1) beta strand to complete the immunoglobulin-like fold of the subunit via a mechanism termed donor strand complementation. The structure of the PapD-PapK complex also suggests that during pilus biogenesis, every subunit completes the immunoglobulin-like fold of its neighboring subunit via a mechanism termed donor strand exchange. | ||
==About this Structure== | ==About this Structure== | ||
1PDK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http:// | 1PDK is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PDK OCA]. | ||
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Fuetterer, K.]] | [[Category: Fuetterer, K.]] | ||
[[Category: Hultgren, S | [[Category: Hultgren, S J.]] | ||
[[Category: Sauer, F | [[Category: Sauer, F G.]] | ||
[[Category: Waksman, G.]] | [[Category: Waksman, G.]] | ||
[[Category: bacterial adhesion]] | [[Category: bacterial adhesion]] | ||
| Line 21: | Line 21: | ||
[[Category: pilus]] | [[Category: pilus]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:27:42 2008'' | ||
