1pfz: Difference between revisions

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==Overview==

Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase, used by Plasmodiumfalciparum to digest hemoglobin during the blood stage, of malaria. A large shift between the N-domain and the central and, C-domains of proplasmepsin II opens the active site cleft, preventing the, formation of a functional aspartic proteinase active site. This mode of, inhibition of catalytic activity has not been observed in any other, aspartic proteinase zymogen. Instead of occluding a pre-formed active, site, as in the gastric aspartic proteinase zymogens, the prosegment of, proplasmepsin II interacts extensively with the C-domain and serves as a, 'harness' to keep the domains apart. Disruption of key salt bridges at low, pH may be important in activation.

Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase used by Plasmodiumfalciparum to digest hemoglobin during the blood stage of malaria. A large shift between the N-domain and the central and C-domains of proplasmepsin II opens the active site cleft, preventing the formation of a functional aspartic proteinase active site. This mode of inhibition of catalytic activity has not been observed in any other aspartic proteinase zymogen. Instead of occluding a pre-formed active site, as in the gastric aspartic proteinase zymogens, the prosegment of proplasmepsin II interacts extensively with the C-domain and serves as a 'harness' to keep the domains apart. Disruption of key salt bridges at low pH may be important in activation.

==About this Structure==

Line 14:

[[Category: Plasmodium falciparum]]

[[Category: Single protein]]

[[Category: Bernstein, N.K.]]

[[Category: Bernstein, N K.]]

[[Category: Cherney, M.M.]]

[[Category: Cherney, M M.]]

[[Category: James, M.N.G.]]

[[Category: James, M N.G.]]

[[Category: Loetscher, H.]]

[[Category: Ridley, R.G.]]

[[Category: Ridley, R G.]]

[[Category: GOL]]

[[Category: aspartic proteinase zymogen]]

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[[Category: malaria]]

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@@ Line 4: / Line 4: @@
 ==Overview==
-Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase, used by Plasmodiumfalciparum to digest hemoglobin during the blood stage, of malaria. A large shift between the N-domain and the central and, C-domains of proplasmepsin II opens the active site cleft, preventing the, formation of a functional aspartic proteinase active site. This mode of, inhibition of catalytic activity has not been observed in any other, aspartic proteinase zymogen. Instead of occluding a pre-formed active, site, as in the gastric aspartic proteinase zymogens, the prosegment of, proplasmepsin II interacts extensively with the C-domain and serves as a, 'harness' to keep the domains apart. Disruption of key salt bridges at low, pH may be important in activation.
+Proplasmepsin II is the zymogen of plasmepsin II, an aspartic proteinase used by Plasmodiumfalciparum to digest hemoglobin during the blood stage of malaria. A large shift between the N-domain and the central and C-domains of proplasmepsin II opens the active site cleft, preventing the formation of a functional aspartic proteinase active site. This mode of inhibition of catalytic activity has not been observed in any other aspartic proteinase zymogen. Instead of occluding a pre-formed active site, as in the gastric aspartic proteinase zymogens, the prosegment of proplasmepsin II interacts extensively with the C-domain and serves as a 'harness' to keep the domains apart. Disruption of key salt bridges at low pH may be important in activation.
 ==About this Structure==
@@ Line 14: / Line 14: @@
 [[Category: Plasmodium falciparum]]
 [[Category: Single protein]]
-[[Category: Bernstein, N.K.]]
+[[Category: Bernstein, N K.]]
-[[Category: Cherney, M.M.]]
+[[Category: Cherney, M M.]]
-[[Category: James, M.N.G.]]
+[[Category: James, M N.G.]]
 [[Category: Loetscher, H.]]
-[[Category: Ridley, R.G.]]
+[[Category: Ridley, R G.]]
 [[Category: GOL]]
 [[Category: aspartic proteinase zymogen]]
@@ Line 27: / Line 27: @@
 [[Category: malaria]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb  3 09:59:54 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:28:24 2008''