1pmi: Difference between revisions
From Proteopedia
Jump to navigationJump to search
New page: left|200px<br /><applet load="1pmi" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pmi, resolution 1.7Å" /> '''HUMAN RANTES'''<br />... |
No edit summary |
||
| Line 1: | Line 1: | ||
[[Image:1pmi.gif|left|200px]]<br /><applet load="1pmi" size=" | [[Image:1pmi.gif|left|200px]]<br /><applet load="1pmi" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1pmi, resolution 1.7Å" /> | caption="1pmi, resolution 1.7Å" /> | ||
'''HUMAN RANTES'''<br /> | '''HUMAN RANTES'''<br /> | ||
==Overview== | ==Overview== | ||
Phosphomannose isomerase (PMI) catalyses the reversible isomerization of | Phosphomannose isomerase (PMI) catalyses the reversible isomerization of fructose-6-phosphate (F6P) and mannose-6-phosphate (M6P). Absence of PMI activity in yeasts causes cell lysis and thus the enzyme is a potential target for inhibition and may be a route to antifungal drugs. The 1.7 A crystal structure of PMI from Candida albicans shows that the enzyme has three distinct domains. The active site lies in the central domain, contains a single essential zinc atom, and forms a deep, open cavity of suitable dimensions to contain M6P or F6P The central domain is flanked by a helical domain on one side and a jelly-roll like domain on the other. | ||
==About this Structure== | ==About this Structure== | ||
1PMI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans] with ZN as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mannose-6-phosphate_isomerase Mannose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.8 5.3.1.8] Full crystallographic information is available from [http:// | 1PMI is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Candida_albicans Candida albicans] with <scene name='pdbligand=ZN:'>ZN</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Mannose-6-phosphate_isomerase Mannose-6-phosphate isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.3.1.8 5.3.1.8] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PMI OCA]. | ||
==Reference== | ==Reference== | ||
| Line 14: | Line 14: | ||
[[Category: Mannose-6-phosphate isomerase]] | [[Category: Mannose-6-phosphate isomerase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Bernard, A | [[Category: Bernard, A R.]] | ||
[[Category: Cleasby, A.]] | [[Category: Cleasby, A.]] | ||
[[Category: Davies, G | [[Category: Davies, G J.]] | ||
[[Category: Hubbard, R | [[Category: Hubbard, R E.]] | ||
[[Category: Payton, M | [[Category: Payton, M A.]] | ||
[[Category: Proudfoot, A | [[Category: Proudfoot, A E.I.]] | ||
[[Category: Skarzynski, T.]] | [[Category: Skarzynski, T.]] | ||
[[Category: Wells, T | [[Category: Wells, T N.C.]] | ||
[[Category: Wonacott, A.]] | [[Category: Wonacott, A.]] | ||
[[Category: ZN]] | [[Category: ZN]] | ||
[[Category: aldose-ketose isomerase]] | [[Category: aldose-ketose isomerase]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:30:17 2008'' | ||
