Tutorial:Basic Chemistry Topics: Difference between revisions
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=='''Summary: Scientific Research Artical'''== | =='''Summary: Scientific Research Artical'''== | ||
:The study where this molecule was obtained is named "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and | :The study where this molecule was obtained is named "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A | ||
Tobramycin". The study focused on AAC (2’)- Ic, also known as aminoglycoside 2’- N- acetyltransferase. AAC(2’)-Ic is an enzyme, which is a compound that speeds the rate of a reaction to form a change in structure in another molecule. The conformational change, or change in structure, produces either a pathological (undesirable affect on the body) or physiological response (normal response of the body). <ref name="Article">Vetting, M. W., et al. "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin." RCSB Protien DataBase. N.p., 28 Aug.2002. Web. 13 July 2011. http://www.rcsb.org/pdb/explore/explore.do?structureId=1M4D</ref>. | and Tobramycin". The study focused on AAC (2’)- Ic, also known as aminoglycoside 2’- N- acetyltransferase. AAC(2’)-Ic is an enzyme, which is a compound that speeds the rate of a reaction to form a change in structure in another molecule. The conformational change, or change in structure, produces either a pathological (undesirable affect on the body) or physiological response (normal response of the body). <ref name="Article">Vetting, M. W., et al. "Aminoglycoside 2'-N-acetyltransferase from Mycobacterium tuberculosis-Complex with Coenzyme A and Tobramycin." RCSB Protien DataBase. N.p., 28 Aug.2002. Web. 13 July 2011. http://www.rcsb.org/pdb/explore/explore.do?structureId=1M4D</ref>. | ||
The scientists involved in the study determined the structural orientation of AAC (2’)-Ic from Mycobacterium tuberculosis, a pathogen. The specific protein fold, or orientation of atoms within AAC (2’)-Ic, is placed in the GNAT or GCN5-related N-acetyltransferase superfamily. The protein fold is important because it determines the function of a compound. The GNAT superfamily is a group of enzymes that are similar in structure. Due to the similarity in structure, they also have similar functions.<ref name="Article" /> | The scientists involved in the study determined the structural orientation of AAC (2’)-Ic from Mycobacterium tuberculosis, a pathogen. The specific protein fold, or orientation of atoms within AAC (2’)-Ic, is placed in the GNAT or GCN5-related N-acetyltransferase superfamily. The protein fold is important because it determines the function of a compound. The GNAT superfamily is a group of enzymes that are similar in structure. Due to the similarity in structure, they also have similar functions.<ref name="Article" /> | ||
