HMG-CoA Reductase: Difference between revisions
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[[Image:1dqa opening.png|300px|left|thumb| Human HMG-CoA Reductase Catalytic Domain, [[1dqa]]]] | [[Image:1dqa opening.png|300px|left|thumb| Human HMG-CoA Reductase Catalytic Domain, [[1dqa]]]] | ||
{{STRUCTURE_1dq8| right| PDB=1dq8 | SCENE=HMG-CoA_Reductase/1dq8_starting_scene/1 |CAPTION= Crystal Structure of Human HMG-CoA | {{STRUCTURE_1dq8| right| PDB=1dq8 | SCENE=HMG-CoA_Reductase/1dq8_starting_scene/1 |CAPTION= Crystal Structure of Human HMG-CoA reductase catalytic domain tetramer [[1dq8]] }} | ||
[[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the Statins, a cholesterol lowering drug class and the best selling pharmaceutical drugs in the world. | [[HMG-CoA Reductase]] (or '''3-hydroxy-3-methyl-glutaryl-CoA reductase''' or '''HMGR''') is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis. HMGR is a transmembrane protein, containing 8 domains, that is anchored in the membrane of the endoplasmic reticulum.<ref name="Roitelman">PMID:1374417</ref> It is the major target of the Statins, a cholesterol lowering drug class and the best selling pharmaceutical drugs in the world. | ||
[[Image: HMG-CoA_reductase_pathway.png|250px|left|thumb| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]] The 1985 Nobel Prize in Physiology or Medicine was awarded to Michael S. Brown and Joseph L. Goldstein, “for their discoveries concerning the regulation of cholesterol metabolism.” Their work on HMGR and LDL elucidated the regulatory complexity of cholesterol synthesis.<ref>http://nobelprize.org/nobel_prizes/medicine/laureates/1985/</ref> | [[Image: HMG-CoA_reductase_pathway.png|250px|left|thumb| Mevalonate Pathway. Note the early stage at which the statins interfere in the pathway]] The 1985 Nobel Prize in Physiology or Medicine was awarded to Michael S. Brown and Joseph L. Goldstein, “for their discoveries concerning the regulation of cholesterol metabolism.” Their work on HMGR and LDL elucidated the regulatory complexity of cholesterol synthesis.<ref>http://nobelprize.org/nobel_prizes/medicine/laureates/1985/</ref> | ||
