Ire1: Difference between revisions

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	<StructureSection load='3lj1' size='400' side='right' caption='Structure of yeast Ire1 cytoplasmic domain complex with inhibitor (PDB entry [[3lj1]])' scene=''>		<StructureSection load='3lj1' size='400' side='right' caption='Structure of yeast Ire1 cytoplasmic domain dimer complex with inhibitor (PDB entry [[3lj1]])' scene=''>

	'''Ire1''' is a serine/threonine protein kinase/endoribonuclease. It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis. The kinase domain of Ire1 is required for activation of the endoribonuclase domain. Ire1 senses unfolded proteins causing its auto-activation.		'''Ire1''' is a serine/threonine protein kinase/endoribonuclease. It is important in altering gene expression as a response to endoplasmic reticulum-based stress signals. The endoribonuclase domain of Ire1 is a transcriptional activator which triggers growth arrest and apoptosis. The kinase domain of Ire1 is required for activation of the endoribonuclase domain. Ire1 senses unfolded proteins causing its auto-activation.

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