Grb10 SH2 Domain: Difference between revisions
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To ensure the crystallographic structure of Grb10 SH2 is indeed a dimer in solution, Evan Stein and colleagues substituted Phe515 at the dimer interface with arginine (electrically charged side chain) and found, using gel filtration chromatography, that the Grb10 SH2 dimer had indeed become independent monomers. | To ensure the crystallographic structure of Grb10 SH2 is indeed a dimer in solution, Evan Stein and colleagues substituted Phe515 at the dimer interface with arginine (electrically charged side chain) and found, using gel filtration chromatography, that the Grb10 SH2 dimer had indeed become independent monomers. | ||
[[Image:Figure_6.jpeg | thumb | alt=text | asdflj]] | |||
</StructureSection> | </StructureSection> | ||
