1ps1: Difference between revisions
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==Overview== | ==Overview== | ||
The crystal structure of pentalenene synthase at 2.6 angstrom resolution | The crystal structure of pentalenene synthase at 2.6 angstrom resolution reveals critical active site features responsible for the cyclization of farnesyl diphosphate into the tricyclic hydrocarbon pentalenene. Metal-triggered substrate ionization initiates catalysis, and the alpha-barrel active site serves as a template to channel and stabilize the conformations of reactive carbocation intermediates through a complex cyclization cascade. The core active site structure of the enzyme may be preserved among the greater family of terpenoid synthases, possibly implying divergence from a common ancestral synthase to satisfy biological requirements for increasingly diverse natural products. | ||
==About this Structure== | ==About this Structure== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptomyces sp.]] | [[Category: Streptomyces sp.]] | ||
[[Category: Transferred entry: 4 | [[Category: Transferred entry: 4 2.3 7]] | ||
[[Category: Christianson, D | [[Category: Christianson, D W.]] | ||
[[Category: Lesburg, C | [[Category: Lesburg, C A.]] | ||
[[Category: PBM]] | [[Category: PBM]] | ||
[[Category: antibiotic biosynthesis]] | [[Category: antibiotic biosynthesis]] | ||
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[[Category: sesquiterpene cyclase]] | [[Category: sesquiterpene cyclase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:32:00 2008'' | ||
