1pyn: Difference between revisions
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New page: left|200px<br /> <applet load="1pyn" size="450" color="white" frame="true" align="right" spinBox="true" caption="1pyn, resolution 2.20Å" /> '''DUAL-SITE POTENT, S... |
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[[Image:1pyn.gif|left|200px]]<br /> | [[Image:1pyn.gif|left|200px]]<br /><applet load="1pyn" size="350" color="white" frame="true" align="right" spinBox="true" | ||
<applet load="1pyn" size=" | |||
caption="1pyn, resolution 2.20Å" /> | caption="1pyn, resolution 2.20Å" /> | ||
'''DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE'''<br /> | '''DUAL-SITE POTENT, SELECTIVE PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR USING A LINKED FRAGMENT STRATEGY AND A MALONATE HEAD ON THE FIRST SITE'''<br /> | ||
==Overview== | ==Overview== | ||
A salicylate second site binder was linked to three classes of | A salicylate second site binder was linked to three classes of phosphotyrosine mimetics to produce potent protein tyrosine phosphatase 1B (PTP1B) inhibitors which exhibit significant selectivity against other phosphatases including the most homologous member, TCPTP. | ||
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
1PYN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with 941 as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http:// | 1PYN is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=941:'>941</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PYN OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Abad-Zapatero, C.]] | [[Category: Abad-Zapatero, C.]] | ||
[[Category: Ballaron, S | [[Category: Ballaron, S J.]] | ||
[[Category: Hajduk, P | [[Category: Hajduk, P J.]] | ||
[[Category: Liang, H.]] | [[Category: Liang, H.]] | ||
[[Category: Liu, G.]] | [[Category: Liu, G.]] | ||
[[Category: Lubben, T.]] | [[Category: Lubben, T.]] | ||
[[Category: Stashko, M.]] | [[Category: Stashko, M.]] | ||
[[Category: Szczepankiewicz, B | [[Category: Szczepankiewicz, B G.]] | ||
[[Category: Trevillyan, J | [[Category: Trevillyan, J M.]] | ||
[[Category: Zhonghua, P.]] | [[Category: Zhonghua, P.]] | ||
[[Category: 941]] | [[Category: 941]] | ||
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[[Category: protein tyrosine phosphatase inhibited with dual site]] | [[Category: protein tyrosine phosphatase inhibited with dual site]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:33:56 2008'' | ||
