Grb10 SH2 Domain: Difference between revisions
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====There are 3 interfaces at which Nedd4 C2 and Grb10 SH2 interact:==== | ====There are 3 interfaces at which Nedd4 C2 and Grb10 SH2 interact:==== | ||
<scene name='Grb10_SH2_Domain/Interface_i/3'>Interface I</scene> is the largest of the 3 interfaces between Grb10 SH2 and NEDD4 C2 domains. There are 8 hydrogen bonds formed at this interface, with the least important H bonds formed between <scene name='Grb10_SH2_Domain/Interface_i/2'>ASN519 and LEU177</scene>, for disruption between these two residues with an induced mutation did not inhibit Grb10 SH2 and NEDD4 C2 to complex. <ref>PMID: 20980250</ref> | <scene name='Grb10_SH2_Domain/Interface_i/3'>Interface I</scene> is the largest of the 3 interfaces between Grb10 SH2 and NEDD4 C2 domains. There are 8 hydrogen bonds formed at this interface (<scene name='Grb10_SH2_Domain/Interface_i/4'>3 backbone H-bonds</scene> and <scene name='Grb10_SH2_Domain/Interface_i/5'>4 residue H-bonds</scene>), with the least important H bonds formed between <scene name='Grb10_SH2_Domain/Interface_i/2'>ASN519 and LEU177</scene>, for disruption between these two residues with an induced mutation did not inhibit Grb10 SH2 and NEDD4 C2 to complex. <ref>PMID: 20980250</ref> | ||
