Obscurin: Difference between revisions
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{{ | {{STRUCTURE_2e7b| PDB=2e7b | SIZE=400| SCENE= |right|CAPTION=Obscurin N terminal complex with titin M10 domain, [[2e7b]] }} | ||
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'''Obscurin''' (Obs) is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. | '''Obscurin''' (Obs) is a giant sarcomeric signalling protein expressed in striated muscles. Other giant proteins in the family include titin and nebulin. It is a multidomain protein containing adhesion modules and signaling domains. These domains include: 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with PH domain and 2 serine/thereonine kinase domains. | ||
Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see [[Group:MUZIC:Obscurin]]. | Obscurin binds small ankyrin 1 which is part of the sarcoplasmic reticulum membrane. It associates with the contractile apparatus via binding to titin and sarcomeric myosin. Obscurin is assumed to play a key role in modulating the organization and assembly of sarcomeric reticulum and the myofibril. For more details see [[Group:MUZIC:Obscurin]]. | ||
==3D structures of obscurin== | ==3D structures of obscurin== | ||
[[2e7b]] - hObs Ig domain residues 8-97 – NMR<BR /> | [[2e7b]] - hObs Ig domain residues 8-97 – NMR<BR /> | ||
[[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR /> | [[2eny]] - hObs Ig domain residues 2735-2825 – NMR<BR /> | ||
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[[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR /> | [[2e6q]] - hObsL Ig domain residues 615-713 – NMR<BR /> | ||
[[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR /> | [[2e6p]] - hObsL Ig domain residues 714-804 – NMR<BR /> | ||
[[3knb]], [[2wp3]], [[2wwm]] – hObs N terminal residues 1-105 + titin M10 domain – human<br /> | |||
[[2wwk]] – hObs N terminal residues 1-105 (mutant) + titin M10 domain<br /> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
