Group:MUZIC:MLP: Difference between revisions

Line 15:

== Function and Interactions ==

All three CSRPs are associated with the actin cytoskeleton and have similar functions in different muscle varieties. They up-regulate the myogenesis and have specific roles in the organisation of cytosolic structures in cardiomyocytes. It was also suggested that CSRPs may have a role in stretch sensing<ref name="r2">PMID: 12507422</ref>. MLP (CSRP3) is localized mainly in Z and M-lines in striated muscles. Within the Z-disc, the ~~interaction~~ of CSRP3 with [http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Telethonin telethonin] ~~has~~ been reported previously<ref name="r2">PMID: 12507422</ref>, <ref>PMID: 16407954</ref>, however recent reports demonstrate that this interaction is not existing <ref name="r3">PMID:18505755</ref>. CSRP3 is mainly interacting with [[α-actinin 2]] as well as has been suggested to interact with βI-spectrin, N-RAP (Nebulin-related-anchoring protein) and cofilin2 (CFL2), underlying the essential role of CSRP3 as a scaffold protein in the sarcomere. During myofibrilogenesis CSRP3 has been suggested to form complexes with the muscle helix-loop-helix transcription factors MyoD, MRF4 and myogenin <ref name="r3">PMID:18505755</ref>. Finally, it is essential for the anchorage of calcineurin to the Z line<ref>PMID: 15665106</ref>.

All three CSRPs are associated with the actin cytoskeleton and have similar functions in different muscle varieties. They up-regulate the myogenesis and have specific roles in the organisation of cytosolic structures in cardiomyocytes. It was also suggested that CSRPs may have a role in stretch sensing<ref name="r2">PMID: 12507422</ref>. MLP (CSRP3) is localized mainly in Z and M-lines in striated muscles. Within the Z-disc, the interactions of CSRP3 with [http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Telethonin telethonin] and α-actinin2 have been reported previously<ref name="r2">PMID: 12507422</ref>, <ref>PMID: 16407954</ref>, however recent reports demonstrate that this interaction is not existing <ref name="r3">PMID:18505755</ref>. CSRP3 is mainly interacting with [[α-actinin 2]] as well as has been suggested to interact with βI-spectrin, N-RAP (Nebulin-related-anchoring protein) and cofilin2 (CFL2), underlying the essential role of CSRP3 as a scaffold protein in the sarcomere. During myofibrilogenesis CSRP3 has been suggested to form complexes with the muscle helix-loop-helix transcription factors MyoD, MRF4 and myogenin <ref name="r3">PMID:18505755</ref>. Finally, it is essential for the anchorage of calcineurin to the Z line<ref>PMID: 15665106</ref>.

== Pathology ==

Group:MUZIC:MLP: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 15: / Line 15: @@
 == Function and Interactions ==
-All three CSRPs are associated with the actin cytoskeleton and have similar functions in different muscle varieties. They up-regulate the myogenesis and have specific roles in the organisation of cytosolic structures in cardiomyocytes. It was also suggested that CSRPs may have a role in stretch sensing<ref name="r2">PMID: 12507422</ref>. MLP (CSRP3) is localized mainly in Z and M-lines in striated muscles. Within the Z-disc, the interaction of CSRP3 with [http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Telethonin telethonin] has been reported previously<ref name="r2">PMID: 12507422</ref>, <ref>PMID: 16407954</ref>, however recent reports demonstrate that this interaction is not existing <ref name="r3">PMID:18505755</ref>. CSRP3 is mainly interacting with [[α-actinin 2]] as well as has been suggested to interact with βI-spectrin, N-RAP (Nebulin-related-anchoring protein) and cofilin2 (CFL2), underlying the essential role of CSRP3 as a scaffold protein in the sarcomere. During myofibrilogenesis CSRP3 has been suggested to form complexes with the muscle helix-loop-helix transcription factors MyoD, MRF4 and myogenin <ref name="r3">PMID:18505755</ref>. Finally, it is essential for the anchorage of calcineurin to the Z line<ref>PMID: 15665106</ref>.
+All three CSRPs are associated with the actin cytoskeleton and have similar functions in different muscle varieties. They up-regulate the myogenesis and have specific roles in the organisation of cytosolic structures in cardiomyocytes. It was also suggested that CSRPs may have a role in stretch sensing<ref name="r2">PMID: 12507422</ref>. MLP (CSRP3) is localized mainly in Z and M-lines in striated muscles. Within the Z-disc, the interactions of CSRP3 with [http://www.proteopedia.org/wiki/index.php/Group:MUZIC:Telethonin telethonin] and α-actinin2 have been reported previously<ref name="r2">PMID: 12507422</ref>, <ref>PMID: 16407954</ref>, however recent reports demonstrate that this interaction is not existing <ref name="r3">PMID:18505755</ref>. CSRP3 is mainly interacting with [[α-actinin 2]] as well as has been suggested to interact with βI-spectrin, N-RAP (Nebulin-related-anchoring protein) and cofilin2 (CFL2), underlying the essential role of CSRP3 as a scaffold protein in the sarcomere. During myofibrilogenesis CSRP3 has been suggested to form complexes with the muscle helix-loop-helix transcription factors MyoD, MRF4 and myogenin <ref name="r3">PMID:18505755</ref>. Finally, it is essential for the anchorage of calcineurin to the Z line<ref>PMID: 15665106</ref>.
 == Pathology ==