Grb10 SH2 Domain: Difference between revisions

Grb10 (Growth factor Receptor-Binding protein) is the member of a family of adapter proteins (Grb7 and Grb14) that interacts with tyrosine kinases. <ref name=Guan>PMID: 12551896 </ref> This protein acts as a growth suppressor by competitively binding to insulin receptors and IGF1R [[Insulin-like growth factor 1 receptor]] which prevents other hormones to bind and facilitate chemical reactions within the cell.  It has also been found to interact with E3 Ubiquitin Ligase NEDD4 which promotes the degradation of IGF1R.  New developments in the research of Grb10 have shown that by inhibiting the expression of this gene, mice express a phenotype that has an increase in body mass, improved glucose homeostasis, improved insulin sensitivity and reduced adiposity.  Grb10 knockout mice have a 30% increase in muscle mass, which has designated it to be called the 'Hulk' protein.