Sandbox Reserved 684: Difference between revisions
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=='''Ornithine Transcarbamoylase'''== | =='''Ornithine Transcarbamoylase'''== | ||
===='''Introduction'''==== | ===='''Introduction'''==== | ||
Ornithine | <scene name='Sandbox_Reserved_684/Ornithine_transcarbamoylase/1'>Ornithine Transcarbamoylase</scene> (OTC) is an enzyme that catalyzes the reaction between carbamoyl phosphate and ornithine to form citrulline and phosphate. In plants and microbes, OTC is involved in arginine biosynthesis, but in mammals it is located in the mitochondria and is part of the urea cycle.<ref>http://en.wikipedia.org/wiki/Ornithine_transcarbamylase</ref> | ||
OTC is often associated with Ornithine transcarbamoylase deficiency (OTCD). OTCD is a common urea cycle disorder, and it is a genetic disorder which results in a mutated and ineffective form of the enzyme OTC. OTC is a trimer composed of a monomer and two substrate-binding domains, and it contains an active site in the middle of the protein with three ligands. | OTC is often associated with Ornithine transcarbamoylase deficiency (OTCD). OTCD is a common urea cycle disorder, and it is a genetic disorder which results in a mutated and ineffective form of the enzyme OTC. OTC is a trimer composed of a monomer and two substrate-binding domains, and it contains an active site in the middle of the protein with three ligands. | ||
===='''Structure'''==== | ===='''Structure'''==== | ||
