Sandbox Reserved 390: Difference between revisions
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<StructureSection load='3qx3' size='600' side='right' caption='Structure of the human topoisomeraseIIbcore-DNA cleavage complex stabilized by the anticancer drug etoposide. (PDB entry 3QX3)' scene=''> | <StructureSection load='3qx3' size='600' side='right' caption='Structure of the human topoisomeraseIIbcore-DNA cleavage complex stabilized by the anticancer drug etoposide. (PDB entry 3QX3)' scene=''> | ||
The purpose of this page is to explain a semisynthetic derivative of podophyllotoxin [[Image:PODO.png|thumb|right|50 px|Chemical structure of podophyllotoxin]] (etoposide) that demonstrates antitumor activity by inhibiting DNA topoisomerase II, thereby inhibiting DNA re-ligation which lead to apoptosis of the cancer cell and also, to describe the mechanisms of resistance of etoposide. | The purpose of this page is to explain a semisynthetic derivative of podophyllotoxin [[Image:PODO.png|thumb|right|50 px|Chemical structure of podophyllotoxin]] (etoposide) that demonstrates antitumor activity by inhibiting DNA topoisomerase II, thereby inhibiting DNA re-ligation which lead to apoptosis of the cancer cell and also, to describe the mechanisms of resistance of etoposide. | ||
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==INTRODUCTION == | ==INTRODUCTION == | ||
The research team described the structural basis by which an anticancer drug etoposide kills cancer cells by interacting with its cellular targets human DNA topoisomerase type II<ref>PMID: 21778401</ref>. In the close-up representation of the <scene name='Sandbox_Reserved_390/Top/21'>etoposide-binding site(s),</scene> cartoon-and-stick representation shows the insertion of two etoposide molecules into two cleavage sites [etoposide surrounded by orange mesh that represent active site (etoposide in red & grey representation), the DNA chain is in red and blue, and the magnesium is in green]. | The research team described the structural basis by which an anticancer drug etoposide kills cancer cells by interacting with its cellular targets human DNA topoisomerase type II<ref>PMID: 21778401</ref>. In the close-up representation of the <scene name='Sandbox_Reserved_390/Top/21'>etoposide-binding site(s),</scene> cartoon-and-stick representation shows the insertion of two etoposide molecules into two cleavage sites [etoposide surrounded by orange mesh that represent active site (etoposide in red & grey representation), the DNA chain is in red and blue, and the magnesium is in green]. | ||
