1qh2: Difference between revisions

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[[Image:1qh2.jpg|left|200px]]<br /><applet load="1qh2" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1qh2.jpg|left|200px]]<br /><applet load="1qh2" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1qh2" />

'''CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA'''<br />

==Overview==

Female reproductive tissues of the ornamental tobacco amass high levels of, serine proteinase inhibitors (PIs) for protection against pests and, pathogens. These PIs are produced from a precursor protein composed of six, repeats each with a protease reactive site. Here we show that proteolytic, processing of the precursor generates five single-chain PIs and a, remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and, C-terminal peptide fragments. Surprisingly, PI precursors adopt this, circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the, widespread potato inhibitor II (Pot II) protein family.

Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family.

==About this Structure==

1QH2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA].

1QH2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA].

==Reference==

Line 13:

[[Category: Nicotiana alata]]

[[Category: Protein complex]]

[[Category: Anderson, M.A.]]

[[Category: Anderson, M A.]]

[[Category: Craik, D.J.]]

[[Category: Craik, D J.]]

[[Category: Lee, M.C.S.]]

[[Category: Lee, M C.S.]]

[[Category: Scanlon, M.J.]]

[[Category: Scanlon, M J.]]

[[Category: nicotiana alata]]

[[Category: potato ii trypsin inhibitor]]

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[[Category: serine proteinase inhibitor]]

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@@ Line 1: / Line 1: @@
-[[Image:1qh2.jpg|left|200px]]<br /><applet load="1qh2" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1qh2.jpg|left|200px]]<br /><applet load="1qh2" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1qh2" />
 '''CHYMOTRYPSIN INHIBITOR (C2) FROM NICOTIANA ALATA'''<br />
 ==Overview==
-Female reproductive tissues of the ornamental tobacco amass high levels of, serine proteinase inhibitors (PIs) for protection against pests and, pathogens. These PIs are produced from a precursor protein composed of six, repeats each with a protease reactive site. Here we show that proteolytic, processing of the precursor generates five single-chain PIs and a, remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and, C-terminal peptide fragments. Surprisingly, PI precursors adopt this, circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the, widespread potato inhibitor II (Pot II) protein family.
+Female reproductive tissues of the ornamental tobacco amass high levels of serine proteinase inhibitors (PIs) for protection against pests and pathogens. These PIs are produced from a precursor protein composed of six repeats each with a protease reactive site. Here we show that proteolytic processing of the precursor generates five single-chain PIs and a remarkable two-chain inhibitor formed by disulfide-bond linkage of N- and C-terminal peptide fragments. Surprisingly, PI precursors adopt this circular structure regardless of the number of inhibitor domains, suggesting this bracelet-like conformation is characteristic of the widespread potato inhibitor II (Pot II) protein family.
 ==About this Structure==
-QH2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA].
+QH2 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Nicotiana_alata Nicotiana alata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QH2 OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Nicotiana alata]]
 [[Category: Protein complex]]
-[[Category: Anderson, M.A.]]
+[[Category: Anderson, M A.]]
-[[Category: Craik, D.J.]]
+[[Category: Craik, D J.]]
-[[Category: Lee, M.C.S.]]
+[[Category: Lee, M C.S.]]
-[[Category: Scanlon, M.J.]]
+[[Category: Scanlon, M J.]]
 [[Category: nicotiana alata]]
 [[Category: potato ii trypsin inhibitor]]
@@ Line 22: / Line 22: @@
 [[Category: serine proteinase inhibitor]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Sun Nov 25 04:05:29 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:39:26 2008''