1qse: Difference between revisions

Line 1:

[[Image:1qse.gif|left|200px]]<br />

[[Image:1qse.gif|left|200px]]<br /><applet load="1qse" size="350" color="white" frame="true" align="right" spinBox="true"

<applet load="1qse" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

caption="1qse, resolution 2.8Å" />

'''STRUCTURE OF HUMAN A6-TCR BOUND TO HLA-A2 COMPLEXED WITH ALTERED HTLV-1 TAX PEPTIDE V7R'''<br />

==Overview==

The interactions of three singly substituted peptide variants of the, HTLV-1 Tax peptide bound to HLA-A2 with the A6 T cell receptor have been, studied using T cell assays, kinetic and thermodynamic measurements, and, X-ray crystallography. The three peptide/MHC ligands include weak agonists, and antagonists with different affinities for TCR. The three-dimensional, structures of the three A6-TCR/peptide/HLA-A2 complexes are remarkably, similar to each other and to the wild-type agonist complex, with minor, adjustments at the interface to accommodate the peptide substitutions, (P6A, V7R, and Y8A). The lack of correlation between structural changes, and the type of T cell signals induced provides direct evidence that, different signals are not generated by different ligand-induced, conformational changes in the alphabeta TCR.

The interactions of three singly substituted peptide variants of the HTLV-1 Tax peptide bound to HLA-A2 with the A6 T cell receptor have been studied using T cell assays, kinetic and thermodynamic measurements, and X-ray crystallography. The three peptide/MHC ligands include weak agonists and antagonists with different affinities for TCR. The three-dimensional structures of the three A6-TCR/peptide/HLA-A2 complexes are remarkably similar to each other and to the wild-type agonist complex, with minor adjustments at the interface to accommodate the peptide substitutions (P6A, V7R, and Y8A). The lack of correlation between structural changes and the type of T cell signals induced provides direct evidence that different signals are not generated by different ligand-induced conformational changes in the alphabeta TCR.

==Disease==

Line 11:

Line 10:

==About this Structure==

1QSE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1QSE OCA].

1QSE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QSE OCA].

==Reference==

Line 26:

Line 25:

[[Category: tcr/peptide/mhc complex]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Mon Nov 12 18~~:56:~~10 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:43:09 2008''

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-[[Image:1qse.gif|left|200px]]<br />
+[[Image:1qse.gif|left|200px]]<br /><applet load="1qse" size="350" color="white" frame="true" align="right" spinBox="true"
-<applet load="1qse" size="450" color="white" frame="true" align="right" spinBox="true"
 caption="1qse, resolution 2.8&Aring;" />
 '''STRUCTURE OF HUMAN A6-TCR BOUND TO HLA-A2 COMPLEXED WITH ALTERED HTLV-1 TAX PEPTIDE V7R'''<br />
 ==Overview==
-The interactions of three singly substituted peptide variants of the, HTLV-1 Tax peptide bound to HLA-A2 with the A6 T cell receptor have been, studied using T cell assays, kinetic and thermodynamic measurements, and, X-ray crystallography. The three peptide/MHC ligands include weak agonists, and antagonists with different affinities for TCR. The three-dimensional, structures of the three A6-TCR/peptide/HLA-A2 complexes are remarkably, similar to each other and to the wild-type agonist complex, with minor, adjustments at the interface to accommodate the peptide substitutions, (P6A, V7R, and Y8A). The lack of correlation between structural changes, and the type of T cell signals induced provides direct evidence that, different signals are not generated by different ligand-induced, conformational changes in the alphabeta TCR.
+The interactions of three singly substituted peptide variants of the HTLV-1 Tax peptide bound to HLA-A2 with the A6 T cell receptor have been studied using T cell assays, kinetic and thermodynamic measurements, and X-ray crystallography. The three peptide/MHC ligands include weak agonists and antagonists with different affinities for TCR. The three-dimensional structures of the three A6-TCR/peptide/HLA-A2 complexes are remarkably similar to each other and to the wild-type agonist complex, with minor adjustments at the interface to accommodate the peptide substitutions (P6A, V7R, and Y8A). The lack of correlation between structural changes and the type of T cell signals induced provides direct evidence that different signals are not generated by different ligand-induced conformational changes in the alphabeta TCR.
 ==Disease==
@@ Line 11: / Line 10: @@
 ==About this Structure==
-QSE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1QSE OCA].
+QSE is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QSE OCA].
 ==Reference==
@@ Line 26: / Line 25: @@
 [[Category: tcr/peptide/mhc complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:56:10 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:43:09 2008''