Sandbox Reserved 653: Difference between revisions
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'''Mechanism of Structure:''' | '''Mechanism of Structure:''' | ||
Alpha ketoglutarate is an enzyme from Kreb’s Cycle, which exhibits several biochemical pathways. It reacts with a free amino acid that comes in the form of ketoacids. In addition, a cofactor Pyridoxal-5’-phosphate is added into the reaction in order to yield Glutamate and alpha ketoglutarate within the reaction of transamination by adding an amine to the alpha carbon carbonyl. This reaction involves another amino acid aspartate that uses another enzyme from the TCA cycle oxaloacetate, a reversible step enzyme that interconverts the appropriate amino acid while adding an amine to the actual precursor amino acid. Both of these reactions change the cofactor Pyridoxal-5’-phosphate to Pyridoxal-5’-amine which alters several conformational changes of the protein binding site. There are other cofactors used in this reaction as intermediates through amination for yielding amino acids and regenerating the enzyme precursor from the Kreb’s cycle. [3][5] | |||
[[Image:mechanismAst.png]] | [[Image:mechanismAst.png]] | ||
'''Implications of Possible Actions:''' | '''Implications of Possible Actions:''' | ||
