Sandbox 645: Difference between revisions
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The main goals for future research in this field are: | The main goals for future research in this field are: | ||
i) | |||
ii) | i) The design of better pharmacological agents while also avoiding severe side effects. | ||
ii) Achieving eradication of the virus and possibly a definitive cure for those infected. | |||
As has been mentioned previously, the pol gene of HIV-1 encodes for three enzymes; protease (PR), reverse transcriptase (RT) and integrase (IN). More than 10 drugs targeting two of these enzymes, PR and RT, have been approved by the FDA. At present, there are no clinically useful agents that inhibit the third enzyme, integrase. Researchers are trying to emphasize the proposed drug binding sites on IN in order to find successfully binding inhibitors. This, along with continued research into inhibition design with HIV-1 Protease, will add to the foundation of research into defeating HIV. | As has been mentioned previously, the pol gene of HIV-1 encodes for three enzymes; protease (PR), reverse transcriptase (RT) and integrase (IN). More than 10 drugs targeting two of these enzymes, PR and RT, have been approved by the FDA. At present, there are no clinically useful agents that inhibit the third enzyme, integrase. Researchers are trying to emphasize the proposed drug binding sites on IN in order to find successfully binding inhibitors. This, along with continued research into inhibition design with HIV-1 Protease, will add to the foundation of research into defeating HIV. | ||
