Tutorial:Basic Chemistry Topics: Difference between revisions
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='''Active Site'''= | ='''Active Site'''= | ||
The active site can be described as a pocket where an interaction between complexes produces a chemical reaction. The chemical reaction can be | The active site can be described as a pocket where an interaction between complexes produces a chemical reaction. The chemical reaction can be physiological or pathological. Referring back to our article, the active site is where the acetylation is going to occur. In this depiction of the <scene name='Tutorial:Basic_Chemistry_Topics/Active_site/2'>active site</scene> you can see the pocket where coenzyme A (CoA) will aid the enzyme in the acetylation of tobramycin (Toy), the aminoglycoside antibiotic. The enzyme is the "blob" surrounding the antibiotic and CoA. The enzyme is holding these compounds in a conformation forcing them to react. The acetylation at the active site will cause the antibiotic to be inactive, hence inhibiting the active site. When tobramycin becomes inactivated it is no longer able to aid in the destruction of bacteria. This is what we call antibiotic resistance. | ||
