Tutorial:Basic Chemistry Topics: Difference between revisions
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As discussed in the introduction, AAC(2’) Ic has a similar fold to that of the GNAT superfamily. The GNAT fold described in the study has the function of acetylation, the addition of an acetyl group. An acetyl functional group is composed of CH3CO. It is important to note that the discovery of the GNAT fold lead to the understanding of the function of AAC(2’). The reaction above shows the acetylation of the aminoglycoside antibiotic, causing its inactivity. From the reaction centered above you see the aminoglycoside antibiotic (Ribostamycin) being acted upon by the enzyme AAC(2’). AAC(2’) is adding and acetyl group to the antibiotic using the substrate CoA. On the right side of the arrow you can see the final product of the acetylation, the antibiotic and acyl group bound. The Acetyl group is circled, so you are able to locate it throughout the reaction. <ref name="Article" /> | As discussed in the introduction, AAC(2’) Ic has a similar fold to that of the GNAT superfamily. The GNAT fold described in the study has the function of acetylation, the addition of an acetyl group. An acetyl functional group is composed of CH3CO. It is important to note that the discovery of the GNAT fold lead to the understanding of the function of AAC(2’). The reaction above shows the acetylation of the aminoglycoside antibiotic, causing its inactivity. From the reaction centered above you see the aminoglycoside antibiotic (Ribostamycin) being acted upon by the enzyme AAC(2’). AAC(2’) is adding and acetyl group to the antibiotic using the substrate CoA. On the right side of the arrow you can see the final product of the acetylation, the antibiotic and acyl group bound. The Acetyl group is circled, so you are able to locate it throughout the reaction. <ref name="Article" /> | ||
='''Ligand'''= | ='''Ligand'''= | ||
Ligands are molecules or complexes | <scene name='Tutorial:Basic_Chemistry_Topics/All_ligands/1'>Ligands</scene> are molecules or complexes located within the secondary structures. The ligands are held in a certain conformation by the secondary structure. This conformation contributes to the function of the compound, as mentioned earlier. The amino acids located throughout the protein will react with components of the ligands based on the polararity/nonpolarity and basicity/acidity of the ligand components. The ligands present in the research article complex are <scene name='Tutorial:Basic_Chemistry_Topics/Coa/2'>coenzyme A</scene>, <scene name='Tutorial:Basic_Chemistry_Topics/Tobramycin/1'>tobramycin</scene> and Phosphate-Adenosine-5'-Diphosphate. | ||
The ligands in this complex are present as a <scene name='Tutorial:Basic_Chemistry_Topics/Dimer_labeled/1'>dimer</scene>. A dimer is a chemical structure formed with two identical subunits, connected along their axis. The dimer conformation is sometimes favored over the monomer due to an increase in stability. | |||
The drop-down boxes below provide more information about the ligands present in the study article for those who are interested. | |||
<scene name='Tutorial:Basic_Chemistry_Topics/Coa/2'> | |||
<scene name='Tutorial:Basic_Chemistry_Topics/ | |||
<scene name='Tutorial:Basic_Chemistry_Topics/ | |||
{| class="wikitable collapsible collapsed" | {| class="wikitable collapsible collapsed" | ||
