Tutorial:Basic Chemistry Topics: Difference between revisions
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Tobramycin is an antibiotic which is part of the aminoglycoside family. Aminoglycosides produce antibacterial effects by inhibiting protein synthesis and compromising the structure of the cell wall. By inhibiting protein synthesis of bacteria it prevents the bacteria from replicating. The cell wall is an important structure to bacteria, because it provides the structure and stability to the bacteria. By disrupting the cell wall, the stability of the bacteria is destroyed and ultimately causing bacteria cell death. | Tobramycin is an antibiotic which is part of the aminoglycoside family. Aminoglycosides produce antibacterial effects by inhibiting protein synthesis and compromising the structure of the cell wall. By inhibiting protein synthesis of bacteria it prevents the bacteria from replicating. The cell wall is an important structure to bacteria, because it provides the structure and stability to the bacteria. By disrupting the cell wall, the stability of the bacteria is destroyed and ultimately causing bacteria cell death.<ref name="Tobramycin"/> | ||
Tobramycin targets a variety of bacteria, particularly gram(-) species. Just like all drugs there are side effects associated with tobramycin. Some of the more common side effects are ototoxicity and nephrotoxicity. Ototoxicity is hearing loss and nephrotoxicity is kidney damage. The kidney damage is due to tobramycin reabsorption through the renal tubules. This basically means that tobramycin may be toxic to the kidneys due to prolonged contact time in the kidneys. | Tobramycin targets a variety of bacteria, particularly gram(-) species. Just like all drugs there are side effects associated with tobramycin. Some of the more common side effects are ototoxicity and nephrotoxicity. Ototoxicity is hearing loss and nephrotoxicity is kidney damage. The kidney damage is due to tobramycin reabsorption through the renal tubules. This basically means that tobramycin may be toxic to the kidneys due to prolonged contact time in the kidneys.<ref name="Tobramycin"/> | ||
Tobramycin is a pregnancy category D. Pregnancy categories are assigned to all drugs. They are used to classify how likely the drug is to cause harm to the fetus. The pregnancy categories are A, B, C, D, and X. Pregnancy category A causes no harm to the fetus and pregnancy category X definitely causes harm to the fetus. Since Tobramycin is a pregnancy category D, this is not an optimal choice for a pregnant patient with a gram(-) bacterial infection. | Tobramycin is a pregnancy category D. Pregnancy categories are assigned to all drugs. They are used to classify how likely the drug is to cause harm to the fetus. The pregnancy categories are A, B, C, D, and X. Pregnancy category A causes no harm to the fetus and pregnancy category X definitely causes harm to the fetus. Since Tobramycin is a pregnancy category D, this is not an optimal choice for a pregnant patient with a gram(-) bacterial infection.<ref name="Tobramycin"/> | ||
Tobramycin can be given intravenously, intramuscularly, as an inhalation or ophthalmically. Intravenously (IV) is a route of administration where the drug is administered directly to the vasculature or blood vessels. Intramuscular (IM) injection penetrates through the skin to the muscle. A common example of an intramuscular injection is a flu shot. An inhalation delivers the drug directly into the lungs. An example of inhalation drug administration is an inhaler used for asthmatics. Ophthalmic administration is drug administration directly to the eye, such as an eye drop. <ref name="Tobramycin">"Tobramycin." Wikipedia. Wikipedia, n.d. Web. 26 Nov. 2012.<http://en.wikipedia.org/wiki/Tobramycin>.</ref> | Tobramycin can be given intravenously, intramuscularly, as an inhalation or ophthalmically. Intravenously (IV) is a route of administration where the drug is administered directly to the vasculature or blood vessels. Intramuscular (IM) injection penetrates through the skin to the muscle. A common example of an intramuscular injection is a flu shot. An inhalation delivers the drug directly into the lungs. An example of inhalation drug administration is an inhaler used for asthmatics. Ophthalmic administration is drug administration directly to the eye, such as an eye drop. <ref name="Tobramycin">"Tobramycin." Wikipedia. Wikipedia, n.d. Web. 26 Nov. 2012.<http://en.wikipedia.org/wiki/Tobramycin>.</ref> | ||
