SandboxPKA: Difference between revisions
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<Structure load='1opl' size='400' frame='true' align='right' caption='ABL1 homo-dimer complex' scene='SandboxPKA/Abl1_homo-dimer_complex/1'' /> | <Structure load='1opl' size='400' frame='true' align='right' caption='ABL1 homo-dimer complex' scene='SandboxPKA/Abl1_homo-dimer_complex/1'' /> | ||
The c-Abl protein 1 (ABL1), also known as Abelson kinase, is a non-receptor tyrosine kinase that plays a role in many key processes linked to cell growth and survival. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. | The c-Abl protein 1 (ABL1), also known as Abelson kinase, is a non-receptor tyrosine kinase that plays a role in many key processes linked to cell growth and survival. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. In more than 90% cases, chronic myelogeneous leukemia (CML) is caused by chromosomal abnormality resulting in the formation of a so-called Philadelphia chromosome. This is caused by (9;22) chromosomal-translocation and results in the head-to-tail fusion of the BCR and ABL1, leading a constitutive activation of this tyrosine kinase. | ||
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== '''Structure''' == | == '''Structure''' == | ||
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<StructureSection load='1OPK' size='350' side='right' caption='c-Abl tyrosine kinase' scene='SandboxPKA/Abl1/4'> | <StructureSection load='1OPK' size='350' side='right' caption='c-Abl tyrosine kinase' scene='SandboxPKA/Abl1/4'> | ||
