1rob: Difference between revisions

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[[Image:1rob.gif|left|200px]]<br /><applet load="1rob" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1rob.gif|left|200px]]<br /><applet load="1rob" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1rob, resolution 1.6Å" />

'''STRUCTURE OF THE CRYSTALLINE COMPLEX OF CYTIDYLIC ACID (2'-CMP) WITH RIBONUCLEASE AT 1.6 ANGSTROMS RESOLUTION'''<br />

==Overview==

The X-ray structure of the inhibitor complex of bovine ribonuclease A with, cytidylic acid (2'-CMP) has been determined at 1.6 A resolution and, refined by restrained least squares to R = 0.17 for 11 945 reflections., Binding of the inhibitor molecule to the protein is confirmed to be in the, productive mode associated with enzyme activity. A study of conserved, solvent sites amongst high-resolution structures in the same crystal form, reveals a stabilizing water cluster between the N and C termini.

The X-ray structure of the inhibitor complex of bovine ribonuclease A with cytidylic acid (2'-CMP) has been determined at 1.6 A resolution and refined by restrained least squares to R = 0.17 for 11 945 reflections. Binding of the inhibitor molecule to the protein is confirmed to be in the productive mode associated with enzyme activity. A study of conserved solvent sites amongst high-resolution structures in the same crystal form reveals a stabilizing water cluster between the N and C termini.

==About this Structure==

1ROB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with C2P as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1ROB OCA].

1ROB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=C2P:'>C2P</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ROB OCA].

==Reference==

Line 14:

[[Category: Pancreatic ribonuclease]]

[[Category: Single protein]]

[[Category: Lisgarten, J.N.]]

[[Category: Lisgarten, J N.]]

[[Category: Palmer, R.A.]]

[[Category: Palmer, R A.]]

[[Category: C2P]]

[[Category: hydrolase(endoribonuclease)]]

''Page seeded by [http://~~ispc~~.weizmann.ac.il/oca OCA ] on ~~Wed Nov~~ 21 01:44:~~56 2007~~''

''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:52:59 2008''

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@@ Line 1: / Line 1: @@
-[[Image:1rob.gif|left|200px]]<br /><applet load="1rob" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1rob.gif|left|200px]]<br /><applet load="1rob" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1rob, resolution 1.6&Aring;" />
 '''STRUCTURE OF THE CRYSTALLINE COMPLEX OF CYTIDYLIC ACID (2'-CMP) WITH RIBONUCLEASE AT 1.6 ANGSTROMS RESOLUTION'''<br />
 ==Overview==
-The X-ray structure of the inhibitor complex of bovine ribonuclease A with, cytidylic acid (2'-CMP) has been determined at 1.6 A resolution and, refined by restrained least squares to R = 0.17 for 11 945 reflections., Binding of the inhibitor molecule to the protein is confirmed to be in the, productive mode associated with enzyme activity. A study of conserved, solvent sites amongst high-resolution structures in the same crystal form, reveals a stabilizing water cluster between the N and C termini.
+The X-ray structure of the inhibitor complex of bovine ribonuclease A with cytidylic acid (2'-CMP) has been determined at 1.6 A resolution and refined by restrained least squares to R = 0.17 for 11 945 reflections. Binding of the inhibitor molecule to the protein is confirmed to be in the productive mode associated with enzyme activity. A study of conserved solvent sites amongst high-resolution structures in the same crystal form reveals a stabilizing water cluster between the N and C termini.
 ==About this Structure==
-ROB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with C2P as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1ROB OCA].
+ROB is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=C2P:'>C2P</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ROB OCA].
 ==Reference==
@@ Line 14: / Line 14: @@
 [[Category: Pancreatic ribonuclease]]
 [[Category: Single protein]]
-[[Category: Lisgarten, J.N.]]
+[[Category: Lisgarten, J N.]]
-[[Category: Palmer, R.A.]]
+[[Category: Palmer, R A.]]
 [[Category: C2P]]
 [[Category: hydrolase(endoribonuclease)]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 01:44:56 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:52:59 2008''