1rvt: Difference between revisions

[[Image:1rvt.gif|left|200px]]<br /><applet load="1rvt" size="350" color="white" frame="true" align="right" spinBox="true"  

The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.

1RVT is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Unidentified_influenza_virus Unidentified influenza virus] with <scene name='pdbligand=SIA:'>SIA</scene>, <scene name='pdbligand=GAL:'>GAL</scene> and <scene name='pdbligand=NDG:'>NDG</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RVT OCA].  

[[Category: Daniels, R S.]]

[[Category: Gamblin, S J.]]

[[Category: Haire, L F.]]

[[Category: Russell, R J.]]

[[Category: Skehel, J J.]]

[[Category: Steinhauer, D A.]]

[[Category: Stevens, D J.]]

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