1rxp: Difference between revisions
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New page: left|200px<br /><applet load="1rxp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1rxp, resolution 1.70Å" /> '''STRUCTURE OF TRYPSIN... |
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[[Image:1rxp.gif|left|200px]]<br /><applet load="1rxp" size=" | [[Image:1rxp.gif|left|200px]]<br /><applet load="1rxp" size="350" color="white" frame="true" align="right" spinBox="true" | ||
caption="1rxp, resolution 1.70Å" /> | caption="1rxp, resolution 1.70Å" /> | ||
'''STRUCTURE OF TRYPSIN (ORTHORHOMBIC) WITH 1-(4-TERT-BUTYLCARBAMOYL- PIPERAZINE-1-CARBONYL)-3-(3-GUANIDINO-PROPYL)-4-OXO-AZETIDINE-2-CARBOXYLIC ACID'''<br /> | '''STRUCTURE OF TRYPSIN (ORTHORHOMBIC) WITH 1-(4-TERT-BUTYLCARBAMOYL- PIPERAZINE-1-CARBONYL)-3-(3-GUANIDINO-PROPYL)-4-OXO-AZETIDINE-2-CARBOXYLIC ACID'''<br /> | ||
==Overview== | ==Overview== | ||
A series of nonguanidine N1-activated C4-carboxy azetidinone tryptase | A series of nonguanidine N1-activated C4-carboxy azetidinone tryptase inhibitors was prepared by solid-phase methodology to quickly assess the SAR associated with distal functionality on the N1-activating group. From these studies, potent inhibitors with improved specificity were discovered. | ||
==About this Structure== | ==About this Structure== | ||
1RXP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with CA, SO4 and 169 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] Full crystallographic information is available from [http:// | 1RXP is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus] with <scene name='pdbligand=CA:'>CA</scene>, <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=169:'>169</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RXP OCA]. | ||
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Trypsin]] | [[Category: Trypsin]] | ||
[[Category: Bisacchi, G | [[Category: Bisacchi, G S.]] | ||
[[Category: Jacobson, B.]] | [[Category: Jacobson, B.]] | ||
[[Category: 169]] | [[Category: 169]] | ||
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[[Category: tryptase inhibitor; serine protease; azetidinone]] | [[Category: tryptase inhibitor; serine protease; azetidinone]] | ||
''Page seeded by [http:// | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 14:55:38 2008'' | ||
