1o5d: Difference between revisions

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{{Seed}}
[[Image:1o5d.png|left|200px]]
[[Image:1o5d.png|left|200px]]


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{{STRUCTURE_1o5d|  PDB=1o5d  |  SCENE=  }}  
{{STRUCTURE_1o5d|  PDB=1o5d  |  SCENE=  }}  


===Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)===
===Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)===


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{{ABSTRACT_PUBMED_15522303}}
{{ABSTRACT_PUBMED_15522303}}
==Disease==
Known disease associated with this structure: Factor VII deficiency OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]], Myocardial infarction, decreased susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=227500 227500]]


==About this Structure==
==About this Structure==
1O5D is a 3 chains structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5D OCA].  
[[1o5d]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O5D OCA].  


==Reference==
==Reference==
<ref group="xtra">PMID:15522303</ref><references group="xtra"/>
<ref group="xtra">PMID:015522303</ref><references group="xtra"/>
[[Category: Coagulation factor VIIa]]
[[Category: Coagulation factor VIIa]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
Line 45: Line 30:
[[Category: Young, W B.]]
[[Category: Young, W B.]]
[[Category: Ala190 upa]]
[[Category: Ala190 upa]]
[[Category: Blood clotting]]
[[Category: Conserved water displacement hydrogen bond deficit]]
[[Category: Conserved water displacement hydrogen bond deficit]]
[[Category: Factor viia]]
[[Category: Factor viia]]
[[Category: Hepsin]]
[[Category: Hepsin]]
[[Category: Hydrolase]]
[[Category: S1 site]]
[[Category: S1 site]]
[[Category: Selectivity]]
[[Category: Selectivity]]
[[Category: Thrombin]]
[[Category: Thrombin]]
[[Category: Trypsin]]
[[Category: Trypsin]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:22:40 2009''

Revision as of 20:53, 5 December 2012

File:1o5d.png

Template:STRUCTURE 1o5d

Dissecting and Designing Inhibitor Selectivity Determinants at the S1 site Using an Artificial Ala190 Protease (Ala190 uPA)

Template:ABSTRACT PUBMED 15522303

About this Structure

1o5d is a 3 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  1. Katz BA, Luong C, Ho JD, Somoza JR, Gjerstad E, Tang J, Williams SR, Verner E, Mackman RL, Young WB, Sprengeler PA, Chan H, Mortara K, Janc JW, McGrath ME. Dissecting and designing inhibitor selectivity determinants at the S1 site using an artificial Ala190 protease (Ala190 uPA). J Mol Biol. 2004 Nov 19;344(2):527-47. PMID:15522303 doi:10.1016/j.jmb.2004.09.032

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