1mx5: Difference between revisions

Revision as of 21:28, 5 December 2012

Ligands:

CL, HTQ, NAG, NDG, SIA

Activity:

Carboxylesterase, with EC number 3.1.1.1

Related:

1mx1, 1mx9

Structural annotation:
Resources:	CATH : 1Mx5A00, 1Mx5B00, 1Mx5C00, 1Mx5D00, 1Mx5E00, 1Mx5F00 InterPro : Ipr002018 Pfam : PF00135 SCOP : d1mx5a_, d1mx5b_, d1mx5c_, d1mx5d_, d1mx5e_, d1mx5f_ UniProt : P23141

Functional annotation:
Cellular component:	endoplasmic reticulum extracellular space
Biological process:	response to toxin metabolic process
Molecular function:	carboxylesterase activity hydrolase activity

Evolutionary conservation:

Toggle Conservation Colors:	Rows = identical sequences:
Further Information:	Caveats, Explanation, Complete Results at ConSurfDB

Resources:

FirstGlance, OCA, RCSB, PDBsum

Coordinates:

save as pdb, mmCIF, xml

1mx5 is a 6 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Bencharit S, Morton CL, Xue Y, Potter PM, Redinbo MR. Structural basis of heroin and cocaine metabolism by a promiscuous human drug-processing enzyme. Nat Struct Biol. 2003 May;10(5):349-56. PMID:12679808 doi:10.1038/nsb919

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