Caspase: Difference between revisions

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{{STRUCTURE_1pyo| PDB=1pyo | SIZE=400| SCENE= |right| CAPTION=CASP-1 subunit ~~P20~~ (grey) and subunit ~~P10~~ (green) complex with polypeptide inhibitor, ~~benzyl chlorocarbonate~~ and ~~fluoro methane~~, [[1pyo]] }}

{{STRUCTURE_1pyo| PDB=1pyo | SIZE=400| SCENE= |right| CAPTION=CASP-2 subunit P18 (grey, pink) and subunit P12 (green, yellow) complex with polypeptide inhibitor (magenta, cyan), aspartic aldehyde and acetyl group, [[1pyo]] }}

'''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis. CASP-1 details in [[Human Caspase-1]]. CASP-6 details in [[Molecular Playground/Caspase-6 (new)]]. CASP-7 details in [[Molecular Playground/Caspase-7 Dynamics]]. CASP-9 details in [[Molecular Playground/Caspase-9 Regulation]]. Dronc is an important initiator CASP and drICE is an effector of apoptosis CASP in ''Drosophila melanogaster''. Metacaspase (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi.

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Revision as of 11:26, 12 December 2012 view source Michal Harel (talk \| contribs) 32,831 edits No edit summary ← Older edit		Revision as of 11:33, 12 December 2012 view source Michal Harel (talk \| contribs) 32,831 edits No edit summary Newer edit →
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	{{STRUCTURE_1pyo\| PDB=1pyo \| SIZE=400\| SCENE= \|right\| CAPTION=CASP-1 subunit ~~P20~~ (grey) and subunit ~~P10~~ (green) complex with polypeptide inhibitor, ~~benzyl chlorocarbonate~~ and ~~fluoro methane~~, [[1pyo]] }}		{{STRUCTURE_1pyo\| PDB=1pyo \| SIZE=400\| SCENE= \|right\| CAPTION=CASP-2 subunit P18 (grey, pink) and subunit P12 (green, yellow) complex with polypeptide inhibitor (magenta, cyan), aspartic aldehyde and acetyl group, [[1pyo]] }}

	'''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis. CASP-1 details in [[Human Caspase-1]]. CASP-6 details in [[Molecular Playground/Caspase-6 (new)]]. CASP-7 details in [[Molecular Playground/Caspase-7 Dynamics]]. CASP-9 details in [[Molecular Playground/Caspase-9 Regulation]]. Dronc is an important initiator CASP and drICE is an effector of apoptosis CASP in ''Drosophila melanogaster''. Metacaspase (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi.		'''Caspase''' (CASP) are cysteine-aspartic proteases which function in apoptosis, necrosis and inflammation. Twelve CASP have been identified in human. CASP is synthesized as an inactive pro-CASP with a prodomain which is being cleaved off to render them active. The X-linked inhibitor of apoptosis protein (XIAP) with its baculoviral IAP repeat (BIR) domain is an inhibitor of CASP. CASP-1 cleaves precursor cytokine interleukin 1-β and interleukin 18 into mature protein. CASP-3 interacts with CASP-8 and CASP-9 during cell apoptosis. CASP-1 details in [[Human Caspase-1]]. CASP-6 details in [[Molecular Playground/Caspase-6 (new)]]. CASP-7 details in [[Molecular Playground/Caspase-7 Dynamics]]. CASP-9 details in [[Molecular Playground/Caspase-9 Regulation]]. Dronc is an important initiator CASP and drICE is an effector of apoptosis CASP in ''Drosophila melanogaster''. Metacaspase (MCASP) are arginine/lysine specific CASP. MCASP are found in plants and fungi.