1ssk: Difference between revisions

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[[Image:1ssk.gif|left|200px]]<br /><applet load="1ssk" size="~~450~~" color="white" frame="true" align="right" spinBox="true"

[[Image:1ssk.gif|left|200px]]<br /><applet load="1ssk" size="350" color="white" frame="true" align="right" spinBox="true"

caption="1ssk" />

'''Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein'''<br />

==Overview==

The severe acute respiratory syndrome (SARS) virus belongs to the, Coronaviridea family of viruses. Its virion encodes several proteins, including a replicase and four structural proteins. Here we describe the, three-dimensional structure of the N-terminal domain of the SARS, coronavirus (CoV) nucleocapsid protein. The protein consists of a, five-stranded beta sheet with a folding topology distinct from other, RNA-binding proteins. Single-stranded RNAs bind to the protein surface at, the junction between a flexible, positively charged beta hairpin and the, core structure. NMR-based screening was used to identify low molecular, weight compounds that bind to this site.

The severe acute respiratory syndrome (SARS) virus belongs to the Coronaviridea family of viruses. Its virion encodes several proteins including a replicase and four structural proteins. Here we describe the three-dimensional structure of the N-terminal domain of the SARS coronavirus (CoV) nucleocapsid protein. The protein consists of a five-stranded beta sheet with a folding topology distinct from other RNA-binding proteins. Single-stranded RNAs bind to the protein surface at the junction between a flexible, positively charged beta hairpin and the core structure. NMR-based screening was used to identify low molecular weight compounds that bind to this site.

==About this Structure==

1SSK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://~~ispc~~.weizmann.ac.il/oca-bin/ocashort?id=1SSK OCA].

1SSK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSK OCA].

==Reference==

Line 13:

[[Category: Human sars coronavirus]]

[[Category: Single protein]]

[[Category: Fesik, S.W.]]

[[Category: Fesik, S W.]]

[[Category: Gunasekera, A.]]

[[Category: Hajduk, P.]]

Line 19:

[[Category: Liu, Z.]]

[[Category: Mack, J.]]

[[Category: Olejniczak, E.T.]]

[[Category: Olejniczak, E T.]]

[[Category: Petros, A.M.]]

[[Category: Petros, A M.]]

[[Category: Xu, N.]]

[[Category: Yu, L.]]

[[Category: nucleocapsid protein]]

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@@ Line 1: / Line 1: @@
-[[Image:1ssk.gif|left|200px]]<br /><applet load="1ssk" size="450" color="white" frame="true" align="right" spinBox="true"
+[[Image:1ssk.gif|left|200px]]<br /><applet load="1ssk" size="350" color="white" frame="true" align="right" spinBox="true"
 caption="1ssk" />
 '''Structure of the N-terminal RNA-binding Domain of the SARS CoV Nucleocapsid Protein'''<br />
 ==Overview==
-The severe acute respiratory syndrome (SARS) virus belongs to the, Coronaviridea family of viruses. Its virion encodes several proteins, including a replicase and four structural proteins. Here we describe the, three-dimensional structure of the N-terminal domain of the SARS, coronavirus (CoV) nucleocapsid protein. The protein consists of a, five-stranded beta sheet with a folding topology distinct from other, RNA-binding proteins. Single-stranded RNAs bind to the protein surface at, the junction between a flexible, positively charged beta hairpin and the, core structure. NMR-based screening was used to identify low molecular, weight compounds that bind to this site.
+The severe acute respiratory syndrome (SARS) virus belongs to the Coronaviridea family of viruses. Its virion encodes several proteins including a replicase and four structural proteins. Here we describe the three-dimensional structure of the N-terminal domain of the SARS coronavirus (CoV) nucleocapsid protein. The protein consists of a five-stranded beta sheet with a folding topology distinct from other RNA-binding proteins. Single-stranded RNAs bind to the protein surface at the junction between a flexible, positively charged beta hairpin and the core structure. NMR-based screening was used to identify low molecular weight compounds that bind to this site.
 ==About this Structure==
-SSK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1SSK OCA].
+SSK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Human_sars_coronavirus Human sars coronavirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SSK OCA].
 ==Reference==
@@ Line 13: / Line 13: @@
 [[Category: Human sars coronavirus]]
 [[Category: Single protein]]
-[[Category: Fesik, S.W.]]
+[[Category: Fesik, S W.]]
 [[Category: Gunasekera, A.]]
 [[Category: Hajduk, P.]]
@@ Line 19: / Line 19: @@
 [[Category: Liu, Z.]]
 [[Category: Mack, J.]]
-[[Category: Olejniczak, E.T.]]
+[[Category: Olejniczak, E T.]]
-[[Category: Petros, A.M.]]
+[[Category: Petros, A M.]]
 [[Category: Xu, N.]]
 [[Category: Yu, L.]]
 [[Category: nucleocapsid protein]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 02:37:49 2007''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 15:04:45 2008''