Sandbox Reserved 705: Difference between revisions
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Phosphorylation of conserved residues and binding to PIP2 and protein partners, is necessary for full activation of ERM proteins <ref>PMID:14993232</ref>.The interactions determine the localization of the protein, its function. | Phosphorylation of conserved residues and binding to PIP2 and protein partners, is necessary for full activation of ERM proteins <ref>PMID:14993232</ref>.The interactions determine the localization of the protein, its function. | ||
Merlin shares certain properties with the ERM family : they both have a subcellular localization to cortical action structures and both bind to the integral membrane hyaluronic acid receptor CD44. | Merlin shares certain properties with the ERM family : they both have a subcellular localization to cortical action structures and both bind to the integral membrane hyaluronic acid receptor CD44.<ref>PMID:9330869</ref> | ||
However Merlin-1 has some properties not shared with ERM proteins. | However Merlin-1 has some properties not shared with ERM proteins. | ||
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===CD44=== | ===CD44=== | ||
CD44 is a cell-surface receptor for hyaluronan (HA a ligand). When HA binds to CD44 the complex promotes tumorigenesis it means it promotes tumor invasion and metastasis. Indeed, CD44 is a receptor presents in the TA3 carcinome mammaire cells and Tr6BC1 schwannoma cells and HA allows their growth. | CD44 is a cell-surface receptor for hyaluronan (HA a ligand). When HA binds to CD44 the complex promotes tumorigenesis it means it promotes tumor invasion and metastasis. Indeed, CD44 is a receptor presents in the TA3 carcinome mammaire cells and Tr6BC1 schwannoma cells and HA allows their growth. | ||
Lire ces deux articles pour savoir s'il faut les citer | |||
<ref>PMID:11316791</ref> | <ref>PMID:11316791</ref> | ||
<ref>PMID:9378774</ref> | |||
<scene name='Sandbox_Reserved_705/Global/4'>charged</scene> | <scene name='Sandbox_Reserved_705/Global/4'>charged</scene> | ||
<scene name='Sandbox_Reserved_705/Sheet/3'>hydrophobic,polar</scene> | <scene name='Sandbox_Reserved_705/Sheet/3'>hydrophobic,polar</scene> | ||
