Sandbox Reserved 712: Difference between revisions
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== '''Description''' == | == '''Description''' == | ||
3ggu is a drug resistant HIV protease. Shown is a patient's variant in complex with darunavir. | 3ggu is a drug resistant HIV protease. Shown is a patient's variant in complex with darunavir. | ||
HIV proteases are essential for the functioning of the retrovirus that causes AIDS. HIV needs active proteases to process Gag & Gap - Polymerase polyprotein precursors into mature structural proteins and replicative enzymes. | |||
HIV proteases contain a highly conserved region Asp - Thr - Gly (Asp25, Thr26 and Gly27), with the aspartic residue beeing the active site in the aspartyl protease.(1) | |||
== '''Activity''' == | == '''Activity''' == | ||
