Sandbox Reserved 712: Difference between revisions
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HIV proteases (PR) are essential for the functioning of the retrovirus that causes AIDS. HIV needs active proteases to process Gag & Gap - Polymerase polyprotein precursors into mature structural proteins and replicative enzymes. | HIV proteases (PR) are essential for the functioning of the retrovirus that causes AIDS. HIV needs active proteases to process Gag & Gap - Polymerase polyprotein precursors into mature structural proteins and replicative enzymes. | ||
HIV proteases contain a highly conserved region Asp - Thr - Gly (Asp25, Thr26 and Gly27), with the aspartic residue beeing the active site in the aspartyl protease. | HIV proteases contain a highly conserved region Asp - Thr - Gly (Asp25, Thr26 and Gly27), with the aspartic residue beeing the active site in the aspartyl protease.<ref> PMID:3290901 </ref> | ||
Because of its importance for the life-cycle of the retrovirus, HIV-PR are the major target for anti-HIV treatment. | Because of its importance for the life-cycle of the retrovirus, HIV-PR are the major target for anti-HIV treatment. | ||
